ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2977
Preferred Name Cyclooxygenase-2
Synonyms COX-2 | Cox-2 | Cox2 | Cyclooxygenase-2 | PGH synthase 2 | PGHS-2 | PHS II | Prostaglandin G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | Ptgs2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 2 SINGLE PROTEIN P35355

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095157 Cyclooxygenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0032991 (protein-containing complex)
GO:0043005 (neuron projection)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0019899 (enzyme binding)
GO:0020037 (heme binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0001525 (angiogenesis)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0007566 (embryo implantation)
GO:0007568 (aging)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0008217 (regulation of blood pressure)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009314 (response to radiation)
GO:0009750 (response to fructose)
GO:0010033 (response to organic substance)
GO:0010042 (response to manganese ion)
GO:0010226 (response to lithium ion)
GO:0010243 (response to organonitrogen compound)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010942 (positive regulation of cell death)
GO:0014070 (response to organic cyclic compound)
GO:0019233 (sensory perception of pain)
GO:0019371 (cyclooxygenase pathway)
GO:0030282 (bone mineralization)
GO:0030728 (ovulation)
GO:0031394 (positive regulation of prostaglandin biosynthetic process)
GO:0031622 (positive regulation of fever generation)
GO:0031915 (positive regulation of synaptic plasticity)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033280 (response to vitamin D)
GO:0034097 (response to cytokine)
GO:0034605 (cellular response to heat)
GO:0034612 (response to tumor necrosis factor)
GO:0034644 (cellular response to UV)
GO:0035633 (maintenance of permeability of blood-brain barrier)
GO:0042127 (regulation of cell proliferation)
GO:0042307 (positive regulation of protein import into nucleus)
GO:0042493 (response to drug)
GO:0042633 (hair cycle)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045786 (negative regulation of cell cycle)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045986 (negative regulation of smooth muscle contraction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0046697 (decidualization)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050873 (brown fat cell differentiation)
GO:0051384 (response to glucocorticoid)
GO:0051926 (negative regulation of calcium ion transport)
GO:0070542 (response to fatty acid)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071284 (cellular response to lead ion)
GO:0071318 (cellular response to ATP)
GO:0071456 (cellular response to hypoxia)
GO:0071471 (cellular response to non-ionic osmotic stress)
GO:0071498 (cellular response to fluid shear stress)
GO:0071636 (positive regulation of transforming growth factor beta production)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0090271 (positive regulation of fibroblast growth factor production)
GO:0090336 (positive regulation of brown fat cell differentiation)
GO:0090362 (positive regulation of platelet-derived growth factor production)
GO:0097756 (negative regulation of blood vessel diameter)
GO:0098869 (cellular oxidant detoxification)
GO:1902219 (negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)
GO:1990776 (response to angiotensin)

Target Cross References - Protein

canSAR P35355
IntAct P35355
Reactome R-RNO-197264 (Nicotinamide salvaging.)
R-RNO-2142770 (Synthesis of 15-eicosatetraenoic acid derivatives.)
R-RNO-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
R-RNO-9018677 (Biosynthesis of DHA-derived SPMs.)
R-RNO-9018679 (Biosynthesis of EPA-derived SPMs.)
R-RNO-9025094 (Biosynthesis of DPAn-3 SPMs.)
R-RNO-9027604 (Biosynthesis of electrophilic Omega-3 PUFA oxo-derivatives.)
UniProt P35355 Q64379 Q925V4

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029576 (COX-2.)
IPR037120 (Haem_peroxidase_sf.)
Pfam PF00008 (EGF)
PF03098 (An_peroxidase)