ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2967
Preferred Name Dopamine D1 receptor
Synonyms D(1A) dopamine receptor | D1AR | DRD1 | Dopamine D1 receptor
Organism Bos taurus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(1A) dopamine receptor SINGLE PROTEIN Q95136

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096970 Dopamine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0060170 (ciliary membrane)
GO:0097730 (non-motile cilium)
GO Molecular Function GO:0001588 (dopamine neurotransmitter receptor activity, coupled via Gs)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0035240 (dopamine binding)
GO Biological Process GO:0001659 (temperature homeostasis)
GO:0001661 (conditioned taste aversion)
GO:0001662 (behavioral fear response)
GO:0001932 (regulation of protein phosphorylation)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001975 (response to amphetamine)
GO:0006606 (protein import into nucleus)
GO:0006936 (muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0007617 (mating behavior)
GO:0007625 (grooming behavior)
GO:0007626 (locomotory behavior)
GO:0007628 (adult walking behavior)
GO:0007631 (feeding behavior)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0010628 (positive regulation of gene expression)
GO:0014002 (astrocyte development)
GO:0015872 (dopamine transport)
GO:0019226 (transmission of nerve impulse)
GO:0019228 (neuronal action potential)
GO:0021542 (dentate gyrus development)
GO:0021756 (striatum development)
GO:0021766 (hippocampus development)
GO:0021853 (cerebral cortex GABAergic interneuron migration)
GO:0030335 (positive regulation of cell migration)
GO:0030432 (peristalsis)
GO:0035106 (operant conditioning)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042220 (response to cocaine)
GO:0042311 (vasodilation)
GO:0042493 (response to drug)
GO:0042711 (maternal behavior)
GO:0043987 (histone H3-S10 phosphorylation)
GO:0046323 (glucose import)
GO:0046959 (habituation)
GO:0046960 (sensitization)
GO:0048148 (behavioral response to cocaine)
GO:0051281 (positive regulation of release of sequestered calcium ion into cytosol)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)
GO:0060291 (long-term synaptic potentiation)
GO:0060292 (long term synaptic depression)
GO:0071870 (cellular response to catecholamine stimulus)
GO:1903351 (cellular response to dopamine)

Target Cross References - Protein

canSAR Q95136
Reactome R-BTA-390651 (Dopamine receptors.)
R-BTA-418555 (G alpha (s) signalling events.)
UniProt A4IFG9 Q8WND7 Q95136

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001413 (Dopamine_D1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)