ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2966
Target Type SINGLE PROTEIN
Preferred Name Adenosine deaminase
Synonyms ADA | Adenosine aminohydrolase | Adenosine deaminase
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenosine deaminase SINGLE PROTEIN P56658

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0030054 (cell junction)
GO:0031410 (cytoplasmic vesicle)
GO:0060205 (cytoplasmic membrane-bounded vesicle lumen)
GO Molecular Function GO:0004000 (adenosine deaminase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0019239 (deaminase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006154 (adenosine catabolic process)
GO:0007155 (cell adhesion)
GO:0009117 (nucleotide metabolic process)
GO:0009168 (purine ribonucleoside monophosphate biosynthetic process)
GO:0042110 (T cell activation)
GO:0043103 (hypoxanthine salvage)
GO:0046103 (inosine biosynthetic process)
GO:0060169 (negative regulation of adenosine receptor signaling pathway)

Target Cross References - Protein

canSAR P56658
IntAct P56658
UniProt P56658 Q9MYY1

Target Cross References - Domain

InterPro IPR001365 (A/AMP_deaminase_dom.)
IPR006330 (Ado/ade_deaminase.)
IPR006650 (A/AMP_deam_AS.)
IPR028893 (A_deaminase.)
IPR032466 (Metal_Hydrolase.)
Pfam PF00962 (A_deaminase)

Target Cross References - Structure

PDBe 1KRM 1NDV 1NDW 1NDY 1NDZ 1O5R 1QXL 1UML 1V79 1V7A 1VFL 1W1I 1WXY 1WXZ 2BGN 2E1W 2Z7G
CREDO 1KRM 1NDV 1NDW 1NDY 1NDZ 1O5R 1QXL 1UML 1V79 1V7A 1VFL 1W1I 1WXY 1WXZ 2BGN 2E1W 2Z7G
spacer
spacer