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Target Report Card

Target Name and Classification

Target ID CHEMBL2963
Preferred Name Matrix metalloproteinase 15
Synonyms MMP-15 | MMP15 | MT-MMP 2 | MT2-MMP | MT2MMP | MTMMP2 | Matrix metalloproteinase-15 | Membrane-type matrix metalloproteinase 2 | Membrane-type-2 matrix metalloproteinase | SMCP-2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Matrix metalloproteinase-15 SINGLE PROTEIN P51511

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102996
Ensembl ENSG00000102996
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031012 (extracellular matrix)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005515 (protein binding)
GO:0008047 (enzyme activator activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0006464 (cellular protein modification process)
GO:0006508 (proteolysis)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0032355 (response to estradiol)
GO:0035987 (endodermal cell differentiation)
GO:0043085 (positive regulation of catalytic activity)
Wikipedia MMP15

Target Cross References - Protein

canSAR P51511
Human Protein Atlas ENSG00000102996
IntAct P51511
Guide to Pharmacology 1639
Open Targets ENSG00000102996
PharmGKB PA30873
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
UniProt A0A2U6 P51511 Q14111

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR021805 (Pept_M10A_metallopeptidase_C.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR028729 (MMP15.)
IPR033739 (M10A_MMP.)
IPR036365 (PGBD-like_sf.)
IPR036375 (Hemopexin-like_dom_sf.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)
PF11857 (DUF3377)