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Target Report Card

Target Name and Classification

Target ID CHEMBL2958
Preferred Name Adenylate cyclase type II
Synonyms AC2 | ATP pyrophosphate-lyase 2 | Adcy2 | Adenylate cyclase type 2 | Adenylate cyclase type II | Adenylyl cyclase 2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 2 SINGLE PROTEIN P26769

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095179 Adenylate cyclase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005622 (intracellular)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008074 (guanylate cyclase complex, soluble)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030425 (dendrite)
GO:0032991 (macromolecular complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004016 (adenylate cyclase activity)
GO:0004383 (guanylate cyclase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008179 (adenylate cyclase binding)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO:0030145 (manganese ion binding)
GO:0031683 (G-protein beta/gamma-subunit complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006171 (cAMP biosynthetic process)
GO:0006182 (cGMP biosynthetic process)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0019933 (cAMP-mediated signaling)
GO:0035556 (intracellular signal transduction)
GO:1904322 (cellular response to forskolin)

Target Cross References - Protein

canSAR P26769
IntAct P26769
TIMBAL Adenylyl%20Cyclase
UniProt P26769

Target Cross References - Domain

InterPro IPR001054 (A/G_cyclase.)
IPR009398 (Adcy_conserved_dom.)
IPR018297 (A/G_cyclase_CS.)
IPR029787 (Nucleotide_cyclase.)
IPR030672 (Adcy.)
IPR032628 (AC_N.)
Pfam PF00211 (Guanylate_cyc)
PF06327 (DUF1053)
PF16214 (AC_N)

Target Cross References - Structure

PDBe 1AB8 1AZS 1CJK 1CJT 1CJU 1CJV 1CS4 1CUL 1TL7 1U0H 2GVD 2GVZ 3C14 3C15 3C16 3G82 3MAA
CREDO 1AB8 1AZS 1CJK 1CJT 1CJU 1CJV 1CS4 1CUL 1TL7 1U0H 2GVD 2GVZ 3C14 3C15 3C16 3G82 3MAA