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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2939
Target Type SINGLE PROTEIN
Preferred Name MAP kinase p38 delta
Synonyms MAP kinase 13 | MAP kinase p38 delta | MAPK 13 | MAPK13 | Mitogen-activated protein kinase 13 | Mitogen-activated protein kinase p38 delta | PRKM13 | SAPK4 | Stress-activated protein kinase 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase p38 subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 13 SINGLE PROTEIN O15264

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094115 MAP kinase p38 PROTEIN FAMILY
CHEMBL3038503 p38 delta/gamma PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000156711
Ensembl ENSG00000156711
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006970 (response to osmotic stress)
GO:0007049 (cell cycle)
GO:0010468 (regulation of gene expression)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0034644 (cellular response to UV)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0050729 (positive regulation of inflammatory response)
GO:0051403 (stress-activated MAPK cascade)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071347 (cellular response to interleukin-1)
GO:0072709 (cellular response to sorbitol)
GO:0072740 (cellular response to anisomycin)
GO:1903936 (cellular response to sodium arsenite)

Target Cross References - Protein

canSAR O15264
Human Protein Atlas ENSG00000156711
IntAct O15264
Guide to Pharmacology 1502
Open Targets ENSG00000156711
PharmGKB PA30620
Pharos O15264 (Tchem)
Reactome R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-171007 (p38MAPK events.)
R-HSA-376172 (DSCAM interactions.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
UniProt O14739 O15124 O15264 Q5U4A5 Q6FI46 Q9UNU0

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003527 (MAP_kinase_CS.)
IPR008352 (MAPK_p38.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
CREDO 3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
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