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Target Report Card

Target Name and Classification

Target ID CHEMBL2933
Target Type SINGLE PROTEIN
Preferred Name Potassium-transporting ATPase alpha chain 2
Synonyms ATP12A | ATP1AL1 | Non-gastric H(+)/K(+) ATPase subunit alpha | Potassium-transporting ATPase alpha chain 2 | Proton pump
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > p-type atpase > hydrogen potassium atpase
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Potassium-transporting ATPase alpha chain 2 SINGLE PROTEIN P54707

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000075673
Ensembl ENSG00000075673
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005889 (hydrogen:potassium-exchanging ATPase complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005391 (sodium:potassium-exchanging ATPase activity)
GO:0005524 (ATP binding)
GO:0008900 (hydrogen:potassium-exchanging ATPase activity)
GO:0016787 (hydrolase activity)
GO:0019829 (cation-transporting ATPase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0006814 (sodium ion transport)
GO:0006883 (cellular sodium ion homeostasis)
GO:0006885 (regulation of pH)
GO:0010038 (response to metal ion)
GO:0010107 (potassium ion import)
GO:0010248 (establishment or maintenance of transmembrane electrochemical gradient)
GO:0014070 (response to organic cyclic compound)
GO:0015991 (ATP hydrolysis coupled proton transport)
GO:0015992 (proton transport)
GO:0030001 (metal ion transport)
GO:0030007 (cellular potassium ion homeostasis)
GO:0034220 (ion transmembrane transport)
GO:0036376 (sodium ion export from cell)
GO:0055075 (potassium ion homeostasis)
Wikipedia ATP12A

Target Cross References - Protein

canSAR P54707
Human Protein Atlas ENSG00000075673
IntAct P54707
Open Targets ENSG00000075673
PharmGKB PA25104
Reactome R-HSA-936837 (Ion transport by P-type ATPases.)
UniProt P54707 Q13816 Q13817 Q16734 Q5W035 Q8N5U2

Target Cross References - Domain

InterPro IPR001757 (P_typ_ATPase.)
IPR004014 (ATPase_P-typ_cation-transptr_N.)
IPR005775 (P-type_ATPase_IIC.)
IPR006068 (ATPase_P-typ_cation-transptr_C.)
IPR008250 (ATPase_P-typ_transduc_dom_A.)
IPR018303 (ATPase_P-typ_P_site.)
IPR023214 (HAD-like_dom.)
IPR023298 (ATPase_P-typ_TM_dom.)
IPR023299 (ATPase_P-typ_cyto_domN.)
IPR030318 (Atp12a.)
Pfam PF00122 (E1-E2_ATPase)
PF00689 (Cation_ATPase_C)
PF00690 (Cation_ATPase_N)
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