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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2931
Target Type SINGLE PROTEIN
Preferred Name Aldehyde dehydrogenase 1A1
Synonyms ALDH-E1 | ALHDII | Aldehyde dehydrogenase family 1 member A1 | Aldehyde dehydrogenase, cytosolic | Aldh | Aldh1a1 | RALDH 1 | RalDH1 | Retinal dehydrogenase 1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Retinal dehydrogenase 1 SINGLE PROTEIN P51647

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0001758 (retinal dehydrogenase activity)
GO:0004028 (3-chloroallyl aldehyde dehydrogenase activity)
GO:0004029 (aldehyde dehydrogenase (NAD) activity)
GO:0016491 (oxidoreductase activity)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO:0018479 (benzaldehyde dehydrogenase (NAD+) activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0001822 (kidney development)
GO:0001889 (liver development)
GO:0002138 (retinoic acid biosynthetic process)
GO:0006979 (response to oxidative stress)
GO:0007494 (midgut development)
GO:0008152 (metabolic process)
GO:0014070 (response to organic cyclic compound)
GO:0032355 (response to estradiol)
GO:0032526 (response to retinoic acid)
GO:0042493 (response to drug)
GO:0042572 (retinol metabolic process)
GO:0042905 (9-cis-retinoic acid metabolic process)
GO:0044849 (estrous cycle)
GO:0045471 (response to ethanol)
GO:0051289 (protein homotetramerization)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

canSAR P51647
UniProt O09184 P51647

Target Cross References - Domain

InterPro IPR015590 (Aldehyde_DH_dom.)
IPR016160 (Ald_DH_CS_CYS.)
IPR016161 (Ald_DH/histidinol_DH.)
IPR016162 (Ald_DH_N.)
IPR016163 (Ald_DH_C.)
IPR029510 (Ald_DH_CS_GLU.)
Pfam PF00171 (Aldedh)
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