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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL292
Target Type SINGLE PROTEIN
Preferred Name GABA receptor alpha-4 subunit
Synonyms GABA(A) receptor subunit alpha-4 | Gabra4 | Gamma-aminobutyric acid receptor subunit alpha-4
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > gaba-a receptor

Target Components

Component Description Relationship Accession
Gamma-aminobutyric acid receptor subunit alpha-4 SINGLE PROTEIN P28471

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096683 Benzodiazepine receptors; peripheral & central SELECTIVITY GROUP
CHEMBL1907607 GABA-A receptor; anion channel PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0034707 (chloride channel complex)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:1902711 (GABA-A receptor complex)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004890 (GABA-A receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006821 (chloride transport)
GO:0007214 (gamma-aminobutyric acid signaling pathway)
GO:0007417 (central nervous system development)
GO:0034220 (ion transmembrane transport)
GO:1902476 (chloride transmembrane transport)
GO:2001023 (regulation of response to drug)

Target Cross References - Protein

canSAR P28471
IntAct P28471
Guide to Pharmacology 407
Reactome R-RNO-977441 (GABA A receptor activation.)
UniProt P28471

Target Cross References - Domain

InterPro IPR001390 (GABAAa_rcpt.)
IPR005434 (GABBAa4_rcpt.)
IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)
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