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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2919
Target Type SINGLE PROTEIN
Preferred Name Glutamate receptor ionotropic kainate 1
Synonyms GluK1 | GluR-5 | GluR5 | Glur5 | Glutamate receptor 5 | Glutamate receptor ionotropic, kainate 1 | Grik1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > kainate receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, kainate 1 SINGLE PROTEIN P22756

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094119 Glutamate receptor ionotropic, kainate PROTEIN COMPLEX GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0008328 (ionotropic glutamate receptor complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043195 (terminal bouton)
GO:0043235 (receptor complex)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0015277 (kainate selective glutamate receptor activity)
GO:0016595 (glutamate binding)
GO:0022843 (voltage-gated cation channel activity)
GO:0038023 (signaling receptor activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006811 (ion transport)
GO:0007268 (chemical synaptic transmission)
GO:0007399 (nervous system development)
GO:0032229 (negative regulation of synaptic transmission, GABAergic)
GO:0032230 (positive regulation of synaptic transmission, GABAergic)
GO:0034220 (ion transmembrane transport)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0048167 (regulation of synaptic plasticity)
GO:0048172 (regulation of short-term neuronal synaptic plasticity)
GO:0051967 (negative regulation of synaptic transmission, glutamatergic)
GO:0060079 (excitatory postsynaptic potential)
GO:0098655 (cation transmembrane transport)

Target Cross References - Protein

canSAR P22756
Guide to Pharmacology 450
UniProt P22756

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)

Target Cross References - Structure

PDBe 1TXF 1VSO 1YCJ 2F34 2F35 2F36 2OJT 2PBW 2QS1 2QS2 2QS3 2QS4 2WKY 3C31 3C32 3C33 3C34 3C35 3C36 3GBA 3GBB 3S2V 4DLD 4E0X More...
CREDO 1TXF 1VSO 1YCJ 2F34 2F35 2F36 2OJT 2PBW 2QS1 2QS2 2QS3 2QS4 2WKY 3C31 3C32 3C33 3C34 3C35 3C36 3GBA 3GBB 3S2V 4DLD 4E0X More...
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