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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL291
Target Type SINGLE PROTEIN
Preferred Name Phosphodiesterase 4C
Synonyms DPDE1 | DPDE1 | PDE21 | PDE4C | cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 4 > phosphodiesterase 4c

Target Components

Component Description Relationship Accession
cAMP-specific 3',5'-cyclic phosphodiesterase 4C SINGLE PROTEIN Q08493

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY
CHEMBL2095153 Phosphodiesterase; PDE3 & PDE4 SELECTIVITY GROUP
CHEMBL2093863 Phosphodiesterase 4 PROTEIN FAMILY
CHEMBL2111340 Phosphodiesterase 4 and 5 (PDE4 and PDE5) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105650
Ensembl ENSG00000105650
GO Cellular Component GO:0005615 (extracellular space)
GO:0005829 (cytosol)
GO:0005929 (cilium)
GO:0042995 (cell projection)
GO Molecular Function GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006198 (cAMP catabolic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
Wikipedia PDE4C

Target Cross References - Protein

canSAR Q08493
Human Protein Atlas ENSG00000105650
IntAct Q08493
Guide to Pharmacology 1302
Open Targets ENSG00000105650
PharmGKB PA264
Reactome R-HSA-180024 (DARPP-32 events.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt B3KTC4 Q08493 Q9UN44 Q9UN45 Q9UN46 Q9UPJ6

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR023088 (PDEase.)
IPR023174 (PDEase_CS.)
IPR036971 (PDEase_catalytic_dom_sf.)
Pfam PF00233 (PDEase_I)

Target Cross References - Structure

PDBe 2QYM
CREDO 2QYM
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