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Target Report Card

Target Name and Classification

Target ID CHEMBL2903
Preferred Name Arachidonate 15-lipoxygenase
Synonyms 12-LOX | 12/15-lipoxygenase | 15-LOX | 15-LOX-1 | ALOX15 | Arachidonate 12-lipoxygenase, leukocyte-type | Arachidonate 15-lipoxygenase | Arachidonate omega-6 lipoxygenase | LOG15
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Arachidonate 15-lipoxygenase SINGLE PROTEIN P16050

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000161905
Ensembl ENSG00000161905
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005811 (lipid particle)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0004052 (arachidonate 12-lipoxygenase activity)
GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding)
GO:0008289 (lipid binding)
GO:0016491 (oxidoreductase activity)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0046872 (metal ion binding)
GO:0047977 (hepoxilin-epoxide hydrolase activity)
GO:0050473 (arachidonate 15-lipoxygenase activity)
GO:0051120 (hepoxilin A3 synthase activity)
GO:0051213 (dioxygenase activity)
GO:0097260 (eoxin A4 synthase activity)
GO Biological Process GO:0001503 (ossification)
GO:0002820 (negative regulation of adaptive immune response)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006646 (phosphatidylethanolamine biosynthetic process)
GO:0006691 (leukotriene metabolic process)
GO:0006954 (inflammatory response)
GO:0010811 (positive regulation of cell-substrate adhesion)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0019369 (arachidonic acid metabolic process)
GO:0019372 (lipoxygenase pathway)
GO:0030282 (bone mineralization)
GO:0030838 (positive regulation of actin filament polymerization)
GO:0034116 (positive regulation of heterotypic cell-cell adhesion)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0035358 (regulation of peroxisome proliferator activated receptor signaling pathway)
GO:0035963 (cellular response to interleukin-13)
GO:0042060 (wound healing)
GO:0043277 (apoptotic cell clearance)
GO:0051122 (hepoxilin biosynthetic process)
GO:0055114 (oxidation-reduction process)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071277 (cellular response to calcium ion)
GO:1901074 (regulation of engulfment of apoptotic cell)
GO:2001303 (lipoxin A4 biosynthetic process)
Wikipedia ALOX15

Target Cross References - Protein

canSAR P16050
Human Protein Atlas ENSG00000161905
IntAct P16050
Guide to Pharmacology 1388
Open Targets ENSG00000161905
PharmGKB PA48
Reactome R-HSA-2142691 (Synthesis of Leukotrienes (LT) and Eoxins (EX).)
R-HSA-2142712 (Synthesis of 12-eicosatetraenoic acid derivatives.)
R-HSA-2142770 (Synthesis of 15-eicosatetraenoic acid derivatives.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt A8K2P4 B7ZA11 P16050 Q8N6R7 Q99657

Target Cross References - Domain

InterPro IPR000907 (LipOase.)
IPR001024 (PLAT/LH2_dom.)
IPR001885 (LipOase_mml.)
IPR013819 (LipOase_C.)
IPR020833 (LipOase_Fe_BS.)
IPR020834 (LipOase_CS.)
IPR036226 (LipOase_C_sf.)
IPR036392 (PLAT/LH2_dom_sf.)
Pfam PF00305 (Lipoxygenase)
PF01477 (PLAT)