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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL290
Target Type SINGLE PROTEIN
Preferred Name Phosphodiesterase 3B
Synonyms CGI-PDE B | CGIP1 | CGIPDE1 | Cyclic GMP-inhibited phosphodiesterase B | PDE3B | cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 3 > phosphodiesterase 3b

Target Components

Component Description Relationship Accession
cGMP-inhibited 3',5'-cyclic phosphodiesterase B SINGLE PROTEIN Q13370

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY
CHEMBL2094125 Phosphodiesterase 3 PROTEIN FAMILY
CHEMBL2095153 Phosphodiesterase; PDE3 & PDE4 SELECTIVITY GROUP
CHEMBL2111400 Phosphodiesterase 3 and 5 (PDE3 and PDE5) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000152270
Ensembl ENSG00000152270
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0032045 (guanyl-nucleotide exchange factor complex)
GO Molecular Function GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity)
GO:0004119 (cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0043422 (protein kinase B binding)
GO:0046872 (metal ion binding)
GO:0047555 (3',5'-cyclic-GMP phosphodiesterase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006198 (cAMP catabolic process)
GO:0007162 (negative regulation of cell adhesion)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0016525 (negative regulation of angiogenesis)
GO:0032869 (cellular response to insulin stimulus)
GO:0033629 (negative regulation of cell adhesion mediated by integrin)
GO:0043951 (negative regulation of cAMP-mediated signaling)
GO:0050995 (negative regulation of lipid catabolic process)

Target Cross References - Protein

canSAR Q13370
Human Protein Atlas ENSG00000152270
IntAct Q13370
Guide to Pharmacology 1299
Open Targets ENSG00000152270
PharmGKB PA33127
Reactome R-HSA-165160 (PDE3B signalling.)
R-HSA-418457 (cGMP effects.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt B7ZM37 O00639 Q13370 Q14408 Q6SEI4

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR023174 (PDEase_CS.)
IPR036971 (PDEase_catalytic_dom_sf.)
Pfam PF00233 (PDEase_I)

Target Cross References - Structure

PDBe 1SO2 1SOJ
CREDO 1SO2 1SOJ
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