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Target Report Card

Target Name and Classification

Target ID CHEMBL2899
Preferred Name Brain adenylate cyclase 1
Synonyms ADCY1 | ATP pyrophosphate-lyase 1 | Adenylate cyclase type 1 | Adenylate cyclase type I | Adenylyl cyclase 1 | Ca(2+)/calmodulin-activated adenylyl cyclase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 1 SINGLE PROTEIN Q08828

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097167 Adenylate cyclase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164742
Ensembl ENSG00000164742
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0008074 (guanylate cyclase complex, soluble)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004016 (adenylate cyclase activity)
GO:0004383 (guanylate cyclase activity)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0008294 (calcium- and calmodulin-responsive adenylate cyclase activity)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0003091 (renal water homeostasis)
GO:0006171 (cAMP biosynthetic process)
GO:0006182 (cGMP biosynthetic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007409 (axonogenesis)
GO:0007420 (brain development)
GO:0007616 (long-term memory)
GO:0007623 (circadian rhythm)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0010226 (response to lithium ion)
GO:0019933 (cAMP-mediated signaling)
GO:0034199 (activation of protein kinase A activity)
GO:0035556 (intracellular signal transduction)
GO:0042493 (response to drug)
GO:0042752 (regulation of circadian rhythm)
GO:0048511 (rhythmic process)
GO:0071277 (cellular response to calcium ion)
GO:0071377 (cellular response to glucagon stimulus)
GO:1904322 (cellular response to forskolin)
Wikipedia ADCY1

Target Cross References - Protein

canSAR Q08828
Human Protein Atlas ENSG00000164742
Open Targets ENSG00000164742
PharmGKB PA24560
Reactome R-HSA-163359 (Glucagon signaling in metabolic regulation.)
R-HSA-163615 (PKA activation.)
R-HSA-164378 (PKA activation in glucagon signalling.)
R-HSA-170660 (Adenylate cyclase activating pathway.)
R-HSA-170670 (Adenylate cyclase inhibitory pathway.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-418597 (G alpha (z) signalling events.)
R-HSA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-HSA-442720 (CREB phosphorylation through the activation of Adenylate Cyclase.)
R-HSA-5610787 (Hedgehog 'off' state.)
UniProt A4D2L8 Q08828 Q75MI1

Target Cross References - Domain

InterPro IPR001054 (A/G_cyclase.)
IPR018297 (A/G_cyclase_CS.)
IPR029787 (Nucleotide_cyclase.)
IPR030672 (Adcy.)
IPR032628 (AC_N.)
Pfam PF00211 (Guanylate_cyc)
PF16214 (AC_N)