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Target Report Card

Target Name and Classification

Target ID CHEMBL2897
Preferred Name Dual specificity mitogen-activated protein kinase kinase 4
Synonyms Dual specificity mitogen-activated protein kinase kinase 4 | JNK-activating kinase 1 | JNKK | JNKK1 | MAP kinase kinase 4 | MAP2K4 | MAPK/ERK kinase 4 | MAPKK 4 | MEK 4 | MEK4 | MKK4 | PRKMK4 | SAPK kinase 1 | SAPK/ERK kinase 1 | SAPKK-1 | SAPKK1 | SEK1 | SEK1 | SERK1 | SKK1 | Stress-activated protein kinase kinase 1 | c-Jun N-terminal kinase kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ste protein kinase group > ste protein kinase ste7 family

Target Components

Component Description Relationship Accession
Dual specificity mitogen-activated protein kinase kinase 4 SINGLE PROTEIN P45985

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065559
Ensembl ENSG00000065559
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0030424 (axon)
GO:0032839 (dendrite cytoplasm)
GO:0043204 (perikaryon)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008545 (JUN kinase kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031435 (mitogen-activated protein kinase kinase kinase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007254 (JNK cascade)
GO:0007257 (activation of JUN kinase activity)
GO:0007346 (regulation of mitotic cell cycle)
GO:0009611 (response to wounding)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0032147 (activation of protein kinase activity)
GO:0034393 (positive regulation of smooth muscle cell apoptotic process)
GO:0035897 (proteolysis in other organism)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0045740 (positive regulation of DNA replication)
GO:0051770 (positive regulation of nitric-oxide synthase biosynthetic process)
GO:0061049 (cell growth involved in cardiac muscle cell development)
GO:0071260 (cellular response to mechanical stimulus)
GO:0072709 (cellular response to sorbitol)
GO:2000672 (negative regulation of motor neuron apoptotic process)
Wikipedia MAP2K4

Target Cross References - Protein

canSAR P45985
Human Protein Atlas ENSG00000065559
IntAct P45985
Guide to Pharmacology 2065
Open Targets ENSG00000065559
PharmGKB PA30589
Pharos P45985 (Tchem)
Reactome R-HSA-2559580 (Oxidative Stress Induced Senescence.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-5210891 (Uptake and function of anthrax toxins.)
R-HSA-5684264 (MAP3K8 (TPL2)-dependent MAPK1/3 activation.)
UniProt B2R7N7 B3KYB2 D3DTS5 P45985 Q5U0B8 Q6FHX4 Q6P9H2 Q6PIE6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure