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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2896
Target Type SINGLE PROTEIN
Preferred Name cGMP-dependent protein kinase 2
Synonyms PRKG2 | PRKGR2 | cGK 2 | cGK2 | cGKII | cGMP-dependent protein kinase 2 | cGMP-dependent protein kinase II
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkg family

Target Components

Component Description Relationship Accession
cGMP-dependent protein kinase 2 SINGLE PROTEIN Q13237

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138669
Ensembl ENSG00000138669
GO Cellular Component GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016324 (apical plasma membrane)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004692 (cGMP-dependent protein kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0030553 (cGMP binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0016310 (phosphorylation)
GO:0036289 (peptidyl-serine autophosphorylation)
GO:0051186 (cofactor metabolic process)
GO:0072659 (protein localization to plasma membrane)
GO:2001226 (negative regulation of chloride transport)

Target Cross References - Protein

canSAR Q13237
Human Protein Atlas ENSG00000138669
IntAct Q13237
Guide to Pharmacology 1493
Open Targets ENSG00000138669
PharmGKB PA33778
Pharos Q13237 (Tchem)
Reactome R-HSA-1474151 (Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-418457 (cGMP effects.)
UniProt B4DMX3 E7EPE6 O00125 O60916 Q13237

Target Cross References - Domain

InterPro IPR000595 (cNMP-bd_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002374 (cGMP_dep_kinase.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR014710 (RmlC-like_jellyroll.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR018488 (cNMP-bd_CS.)
IPR018490 (cNMP-bd-like.)
IPR035014 (STKc_cGK.)
Pfam PF00027 (cNMP_binding)
PF00069 (Pkinase)

Target Cross References - Structure

PDBe 5BV6 5C6C 5C8W 5JIX 5JIZ
CREDO 5BV6 5C6C 5C8W 5JIX 5JIZ
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