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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL289
Target Type SINGLE PROTEIN
Preferred Name Cytochrome P450 2D6
Synonyms CYP2D6 | CYP2DL1 | CYPIID6 | Cholesterol 25-hydroxylase | Cytochrome P450 2D6 | Cytochrome P450-DB1 | Debrisoquine 4-hydroxylase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 2 > cytochrome p450 family 2d > cytochrome p450 2d6

Target Components

Component Description Relationship Accession
Cytochrome P450 2D6 SINGLE PROTEIN P10635

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100197 ENSG00000275211
Ensembl ENSG00000100197 ENSG00000275211
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0005506 (iron ion binding)
GO:0008144 (drug binding)
GO:0008392 (arachidonic acid epoxygenase activity)
GO:0008395 (steroid hydroxylase activity)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
GO:0019825 (oxygen binding)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0070330 (aromatase activity)
GO Biological Process GO:0006629 (lipid metabolic process)
GO:0006805 (xenobiotic metabolic process)
GO:0008202 (steroid metabolic process)
GO:0009804 (coumarin metabolic process)
GO:0009820 (alkaloid metabolic process)
GO:0009822 (alkaloid catabolic process)
GO:0016098 (monoterpenoid metabolic process)
GO:0017144 (drug metabolic process)
GO:0019369 (arachidonic acid metabolic process)
GO:0033076 (isoquinoline alkaloid metabolic process)
GO:0042737 (drug catabolic process)
GO:0046483 (heterocycle metabolic process)
GO:0051100 (negative regulation of binding)
GO:0055114 (oxidation-reduction process)
GO:0070989 (oxidative demethylation)
GO:0090350 (negative regulation of cellular organofluorine metabolic process)

Target Cross References - Protein

canSAR P10635
CGD Drug metabolism, CYP2CD6-related
Human Protein Atlas ENSG00000100197 ENSG00000275211
Guide to Pharmacology 1329
Open Targets ENSG00000100197 ENSG00000275211
Reactome R-HSA-211935 (Fatty acids.)
R-HSA-211958 (Miscellaneous substrates.)
R-HSA-211981 (Xenobiotics.)
R-HSA-211999 (CYP2E1 reactions.)
UniProt P10635 Q16752 Q2XND6 Q2XND7 Q2XNE0 Q6B012 Q6NXU8

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR008069 (Cyt_P450_E_grp-I_CYP2D-like.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)

Target Cross References - Structure

PDBe 2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV 4WNW 4XRY 4XRZ 5TFT 5TFU
CREDO 2F9Q 3QM4 3TBG 3TDA 4WNT 4WNU 4WNV 4WNW 4XRY 4XRZ 5TFT 5TFU
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