ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2880
Preferred Name Adenylate cyclase type V
Synonyms ATP pyrophosphate-lyase 5 | Adcy5 | Adenylate cyclase type 5 | Adenylate cyclase type V | Adenylyl cyclase 5
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 5 SINGLE PROTEIN Q04400

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095179 Adenylate cyclase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005929 (cilium)
GO:0008074 (guanylate cyclase complex, soluble)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042383 (sarcolemma)
GO:0042995 (cell projection)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004016 (adenylate cyclase activity)
GO:0004383 (guanylate cyclase activity)
GO:0005524 (ATP binding)
GO:0008294 (calcium- and calmodulin-responsive adenylate cyclase activity)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006171 (cAMP biosynthetic process)
GO:0006182 (cGMP biosynthetic process)
GO:0007165 (signal transduction)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007420 (brain development)
GO:0007507 (heart development)
GO:0007568 (aging)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0010977 (negative regulation of neuron projection development)
GO:0035556 (intracellular signal transduction)
GO:0043278 (response to morphine)
GO:0061178 (regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:1904322 (cellular response to forskolin)

Target Cross References - Protein

canSAR Q04400
TIMBAL Adenylyl%20Cyclase
UniProt Q04400

Target Cross References - Domain

InterPro IPR001054 (A/G_cyclase.)
IPR009398 (Adcy_conserved_dom.)
IPR018297 (A/G_cyclase_CS.)
IPR029787 (Nucleotide_cyclase.)
IPR030672 (Adcy.)
IPR032628 (AC_N.)
Pfam PF00211 (Guanylate_cyc)
PF06327 (DUF1053)
PF16214 (AC_N)