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Target Report Card

Target Name and Classification

Target ID CHEMBL2873
Preferred Name Mitogen-activated protein kinase kinase kinase 10
Synonyms MAP3K10 | MLK2 | MST | Mitogen-activated protein kinase kinase kinase 10 | Mixed lineage kinase 2 | Protein kinase MST
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase mlk family > tkl protein kinase mlk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 10 SINGLE PROTEIN Q02779

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL290352 CEP-1347 Mitogen-activated protein kinase kinase kinase 10 inhibitor 3 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130758
Ensembl ENSG00000130758
GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003714 (transcription corepressor activity)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004706 (JUN kinase kinase kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO:0043425 (bHLH transcription factor binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007224 (smoothened signaling pathway)
GO:0007254 (JNK cascade)
GO:0007256 (activation of JNKK activity)
GO:0007257 (activation of JUN kinase activity)
GO:0008219 (cell death)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0046330 (positive regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
Wikipedia MAP3K10

Target Cross References - Protein

canSAR Q02779
Human Protein Atlas ENSG00000130758
IntAct Q02779
Guide to Pharmacology 2070
Open Targets ENSG00000130758
PharmGKB PA30593
Pharos Q02779 (Tchem)
UniProt Q02779 Q12761 Q14871

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR015785 (MAP3K10.)
IPR016231 (MLK1-4.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR035779 (MLK1-3_SH3.)
IPR036028 (SH3-like_dom_sf.)
Pfam PF07714 (Pkinase_Tyr)
PF14604 (SH3_9)

Target Cross References - Structure