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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2872
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase kinase kinase 9
Synonyms MAP3K9 | MLK1 | Mitogen-activated protein kinase kinase kinase 9 | Mixed lineage kinase 1 | PRKE1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase mlk family > tkl protein kinase mlk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 9 SINGLE PROTEIN P80192

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL290352 CEP-1347 Mitogen-activated protein kinase kinase kinase 9 inhibitor 3 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000006432
Ensembl ENSG00000006432
GO Cellular Component GO:0005575 (cellular_component)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004706 (JUN kinase kinase kinase activity)
GO:0004708 (MAP kinase kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007256 (activation of JNKK activity)
GO:0007257 (activation of JUN kinase activity)
GO:0008219 (cell death)
GO:0016310 (phosphorylation)
GO:0043065 (positive regulation of apoptotic process)
GO:0046777 (protein autophosphorylation)
Wikipedia MAP3K9

Target Cross References - Protein

canSAR P80192
Human Protein Atlas ENSG00000006432
IntAct P80192
Guide to Pharmacology 2084
Open Targets ENSG00000006432
PharmGKB PA30607
Pharos P80192 (Tchem)
UniProt A3KN85 P80192 Q0D2G7 Q6EH31 Q9H2N5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016231 (MLK1-4.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR035779 (MLK1-3_SH3.)
IPR036028 (SH3-like_dom_sf.)
Pfam PF00069 (Pkinase)
PF14604 (SH3_9)

Target Cross References - Structure

PDBe 3DTC 4UY9
CREDO 3DTC 4UY9
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