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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL287
Preferred Name Sigma opioid receptor
Synonyms Aging-associated gene 8 protein | OPRS1 | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma1-receptor | Sigma1R | hSigmaR1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Sigma non-opioid intracellular receptor 1 SINGLE PROTEIN Q99720

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201461 DEXTROMETHORPHAN POLISTIREX Sigma opioid receptor agonist 4 PubMed
CHEMBL1256696 CARBETAPENTANE CITRATE Sigma opioid receptor agonist 4 PMC PubMed PubMed PubMed PubMed PubMed
CHEMBL1256818 DEXTROMETHORPHAN HYDROBROMIDE Sigma opioid receptor agonist 4 PubMed
CHEMBL2106217 FENFLURAMINE HYDROCHLORIDE Sigma opioid receptor antagonist 4 PubMed PubMed PubMed PubMed
CHEMBL3989509 PENTAZOCINE LACTATE Sigma opioid receptor modulator 4 DailyMed PubMed
CHEMBL3989510 PENTAZOCINE HYDROCHLORIDE Sigma opioid receptor modulator 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000147955
Ensembl ENSG00000147955
GO Cellular Component GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005637 (nuclear inner membrane)
GO:0005640 (nuclear outer membrane)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005811 (lipid particle)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030426 (growth cone)
GO:0031410 (cytoplasmic vesicle)
GO:0042995 (cell projection)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004985 (opioid receptor activity)
GO:0008144 (drug binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0006869 (lipid transport)
GO:0007165 (signal transduction)
GO:0007399 (nervous system development)
GO:0038003 (opioid receptor signaling pathway)
GO:0043523 (regulation of neuron apoptotic process)
GO:0070207 (protein homotrimerization)
Wikipedia Sigma-1_receptor

Target Cross References - Protein

canSAR Q99720
CGD Amyotrophic lateral sclerosis 16, juvenile; Frontotemporal lobar degeneration-motor neuron disease
Human Protein Atlas ENSG00000147955
IntAct Q99720
Guide to Pharmacology 2552
MICAD NBK23444 (Sigma receptor)
Open Targets ENSG00000147955
PharmGKB PA164725706
UniProt D3DRM7 O00673 O00725 Q0Z9W6 Q153Z1 Q2TSD1 Q53GN2 Q7Z653 Q8N7H3 Q99720 Q9NYX0

Target Cross References - Domain

InterPro IPR006716 (ERG2_sigma1_rcpt-like.)
Pfam PF04622 (ERG2_Sigma1R)

Target Cross References - Structure

PDBe 5HK1 5HK2