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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2869
Target Type SINGLE PROTEIN
Preferred Name AMP deaminase 1
Synonyms AMP deaminase 1 | AMP deaminase isoform M | AMPD1 | Myoadenylate deaminase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
AMP deaminase 1 SINGLE PROTEIN P23109

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000116748
Ensembl ENSG00000116748
GO Cellular Component GO:0005829 (cytosol)
GO Molecular Function GO:0003876 (AMP deaminase activity)
GO:0016787 (hydrolase activity)
GO:0019239 (deaminase activity)
GO:0032036 (myosin heavy chain binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0009117 (nucleotide metabolic process)
GO:0009168 (purine ribonucleoside monophosphate biosynthetic process)
GO:0010033 (response to organic substance)
GO:0032264 (IMP salvage)
GO:0043101 (purine-containing compound salvage)
Wikipedia AMP_deaminase

Target Cross References - Protein

canSAR P23109
CGD Myoadenylate deaminase deficiency
Human Protein Atlas ENSG00000116748
IntAct P23109
Open Targets ENSG00000116748
PharmGKB PA24776
Reactome R-HSA-74217 (Purine salvage.)
UniProt A8K5N4 B2RAM1 F2Z3B3 P23109 Q5TF00 Q5TF02

Target Cross References - Domain

InterPro IPR001365 (A/AMP_deaminase_dom.)
IPR006329 (AMPD.)
IPR006650 (A/AMP_deam_AS.)
IPR029770 (AMPD1.)
IPR032466 (Metal_Hydrolase.)
Pfam PF00962 (A_deaminase)
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