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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2860
Preferred Name Cyclooxygenase-1
Synonyms COX-1 | COX-1 | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1
Organism Bos taurus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 1 SINGLE PROTEIN O62664

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096674 Cyclooxygenase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0001750 (photoreceptor outer segment)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0008217 (regulation of blood pressure)
GO:0019371 (cyclooxygenase pathway)
GO:0042127 (regulation of cell proliferation)
GO:0055114 (oxidation-reduction process)
GO:0098869 (cellular oxidant detoxification)

Target Cross References - Protein

canSAR O62664
Reactome R-BTA-140180 (COX reactions.)
R-BTA-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
UniProt A7YWD4 O62664

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029580 (COX-1.)
IPR037120 (Haem_peroxidase_sf.)
Pfam PF03098 (An_peroxidase)