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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2855
Target Type SINGLE PROTEIN
Preferred Name Protein kinase C alpha
Synonyms PKC-A | PKC-alpha | Pkca | Prkca | Protein kinase C alpha type
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase pkc family > agc protein kinase pkc alpha subfamily

Target Components

Component Description Relationship Accession
Protein kinase C alpha type SINGLE PROTEIN P05696

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094266 Protein kinase C (PKC) PROTEIN FAMILY
CHEMBL2097168 Protein kinase C, PKC; classical PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031966 (mitochondrial membrane)
GO:0032991 (macromolecular complex)
GO:0043005 (neuron projection)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004697 (protein kinase C activity)
GO:0004698 (calcium-dependent protein kinase C activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008270 (zinc ion binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000302 (response to reactive oxygen species)
GO:0001525 (angiogenesis)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007155 (cell adhesion)
GO:0007568 (aging)
GO:0007611 (learning or memory)
GO:0009612 (response to mechanical stimulus)
GO:0009636 (response to toxic substance)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0014070 (response to organic cyclic compound)
GO:0016310 (phosphorylation)
GO:0017148 (negative regulation of translation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0021955 (central nervous system neuron axonogenesis)
GO:0030335 (positive regulation of cell migration)
GO:0031666 (positive regulation of lipopolysaccharide-mediated signaling pathway)
GO:0032355 (response to estradiol)
GO:0034351 (negative regulation of glial cell apoptotic process)
GO:0035556 (intracellular signal transduction)
GO:0043434 (response to peptide hormone)
GO:0045184 (establishment of protein localization)
GO:0045471 (response to ethanol)
GO:0045651 (positive regulation of macrophage differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0045785 (positive regulation of cell adhesion)
GO:0045822 (negative regulation of heart contraction)
GO:0045921 (positive regulation of exocytosis)
GO:0045931 (positive regulation of mitotic cell cycle)
GO:0046677 (response to antibiotic)
GO:0046777 (protein autophosphorylation)
GO:0048259 (regulation of receptor-mediated endocytosis)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051412 (response to corticosterone)
GO:0051965 (positive regulation of synapse assembly)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0090330 (regulation of platelet aggregation)
GO:2000707 (positive regulation of dense core granule biogenesis)

Target Cross References - Protein

canSAR P05696
IntAct P05696
UniProt P05696

Target Cross References - Domain

InterPro IPR000008 (C2_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002219 (PE/DAG-bd.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR014375 (Protein_kinase_C_a/b/g.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017892 (Pkinase_C.)
IPR020454 (DAG/PE-bd.)
IPR034663 (cPKC_alpha.)
IPR035892 (C2_domain_sf.)
Pfam PF00069 (Pkinase)
PF00130 (C1_1)
PF00168 (C2)
PF00433 (Pkinase_C)

Target Cross References - Structure

PDBe 1DSY 3GPE 3RDJ 3TWY 4L1L
CREDO 1DSY 3GPE 3RDJ 3TWY 4L1L
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