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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2830
Preferred Name Voltage-gated L-type calcium channel alpha-1C subunit
Synonyms CACB-receptor | CACH2 | CACN2 | CACNA1C | CACNL1A1 | CCHL1A1 | Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle | Smooth muscle calcium channel blocker receptor | Voltage-dependent L-type calcium channel subunit alpha-1C | Voltage-gated calcium channel subunit alpha Cav1.2
Organism Oryctolagus cuniculus
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated calcium channel

Target Components

Component Description Relationship Accession
Voltage-dependent L-type calcium channel subunit alpha-1C SINGLE PROTEIN P15381

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3638171 L-type calcium channel alpha 1C/beta 2A PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005891 (voltage-gated calcium channel complex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:1990454 (L-type voltage-gated calcium channel complex)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0008331 (high voltage-gated calcium channel activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0034765 (regulation of ion transmembrane transport)
GO:0055085 (transmembrane transport)
GO:0060402 (calcium ion transport into cytosol)
GO:0061337 (cardiac conduction)
GO:0061577 (calcium ion transmembrane transport via high voltage-gated calcium channel)
GO:0070588 (calcium ion transmembrane transport)
GO:0098903 (regulation of membrane repolarization during action potential)

Target Cross References - Protein

canSAR P15381
IntAct P15381
UniProt P15381 Q03716 Q28676 Q99243

Target Cross References - Domain

InterPro IPR002077 (VDCCAlpha1.)
IPR005446 (VDCC_L_a1su.)
IPR005451 (VDCC_L_a1csu.)
IPR005821 (Ion_trans_dom.)
IPR014873 (VDCC_a1su_IQ.)
IPR027359 (Volt_channel_dom_sf.)
IPR031649 (GPHH_dom.)
IPR031688 (CAC1F_C.)
Pfam PF00520 (Ion_trans)
PF08763 (Ca_chan_IQ)
PF16885 (CAC1F_C)
PF16905 (GPHH)

Target Cross References - Structure