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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL283
Preferred Name Matrix metalloproteinase 3
Synonyms MMP-3 | MMP3 | Matrix metalloproteinase-3 | SL-1 | STMY1 | Stromelysin-1 | Transin-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mam clan > metallo protease m10a subfamily

Target Components

Component Description Relationship Accession
Stromelysin-1 SINGLE PROTEIN P08254

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111321 Matrix metalloproteinase (2 and 3) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL279785 MARIMASTAT Matrix metalloproteinase 3 inhibitor 3 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149968
Ensembl ENSG00000149968
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0031012 (extracellular matrix)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004222 (metalloendopeptidase activity)
GO:0004252 (serine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0010727 (negative regulation of hydrogen peroxide metabolic process)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0022617 (extracellular matrix disassembly)
GO:0030574 (collagen catabolic process)
GO:0032461 (positive regulation of protein oligomerization)
GO:0071732 (cellular response to nitric oxide)
GO:1903209 (positive regulation of oxidative stress-induced cell death)
Wikipedia MMP3

Target Cross References - Protein

canSAR P08254
Human Protein Atlas ENSG00000149968
IntAct P08254
Guide to Pharmacology 1630
Open Targets ENSG00000149968
PharmGKB PA30886
Reactome R-HSA-1442490 (Collagen degradation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-2022090 (Assembly of collagen fibrils and other multimeric structures.)
R-HSA-2179392 (EGFR Transactivation by Gastrin.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt B2R8B8 P08254 Q3B7S0 Q6GRF8

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR018486 (Hemopexin_CS.)
IPR018487 (Hemopexin-like_repeat.)
IPR021158 (Pept_M10A_Zn_BS.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom_sf.)
IPR033739 (M10A_MMP.)
IPR036365 (PGBD-like_sf.)
IPR036375 (Hemopexin-like_dom_sf.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)

Target Cross References - Structure

PDBe 1B3D 1B8Y 1BIW 1BQO 1C3I 1C8T 1CAQ 1CIZ 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 1G49 1G4K 1HFS 1HY7 1QIA 1QIC 1SLM 1SLN 1UEA 1USN More...
CREDO 1B3D 1B8Y 1BIW 1BQO 1C3I 1C8T 1CAQ 1CIZ 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 1G49 1G4K 1HFS 1HY7 1QIA 1QIC 1SLM 1SLN 1UEA 1USN More...