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Target Report Card

Target Name and Classification

Target ID CHEMBL2828
Target Type SINGLE PROTEIN
Preferred Name Casein kinase I delta
Synonyms CKI-delta | CKId | CSNK1D | Casein kinase I isoform delta | HCKID | Tau-protein kinase CSNK1D
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > ck1 protein kinase group > ck1 protein kinase ck1 family

Target Components

Component Description Relationship Accession
Casein kinase I isoform delta SINGLE PROTEIN P48730

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038494 Casein kinase I delta/epsilon PROTEIN COMPLEX
CHEMBL2111458 Casein kinase I PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141551
Ensembl ENSG00000141551
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005876 (spindle microtubule)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0033116 (endoplasmic reticulum-Golgi intermediate compartment membrane)
GO:0043005 (neuron projection)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0042277 (peptide binding)
GO:0045296 (cadherin binding)
GO:0050321 (tau-protein kinase activity)
GO Biological Process GO:0000086 (G2/M transition of mitotic cell cycle)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006364 (rRNA processing)
GO:0006468 (protein phosphorylation)
GO:0006897 (endocytosis)
GO:0007020 (microtubule nucleation)
GO:0007030 (Golgi organization)
GO:0008360 (regulation of cell shape)
GO:0010389 (regulation of G2/M transition of mitotic cell cycle)
GO:0016055 (Wnt signaling pathway)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030177 (positive regulation of Wnt signaling pathway)
GO:0032436 (positive regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0032922 (circadian regulation of gene expression)
GO:0034067 (protein localization to Golgi apparatus)
GO:0042752 (regulation of circadian rhythm)
GO:0048208 (COPII vesicle coating)
GO:0048511 (rhythmic process)
GO:0051225 (spindle assembly)
GO:0061512 (protein localization to cilium)
GO:0071539 (protein localization to centrosome)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:0097711 (ciliary basal body-plasma membrane docking)
GO:1905426 (positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation)
GO:1905515 (non-motile cilium assembly)
GO:1990090 (cellular response to nerve growth factor stimulus)
GO:2000052 (positive regulation of non-canonical Wnt signaling pathway)
Wikipedia CSNK1D

Target Cross References - Protein

canSAR P48730
CGD Advanced sleep-phase syndrome, familial, 2
Human Protein Atlas ENSG00000141551
IntAct P48730
Guide to Pharmacology 1997
Open Targets ENSG00000141551
PharmGKB PA26952
Pharos P48730 (Tchem)
Reactome R-HSA-204005 (COPII (Coat Protein 2) Mediated Vesicle Transport.)
R-HSA-2565942 (Regulation of PLK1 Activity at G2/M Transition.)
R-HSA-380259 (Loss of Nlp from mitotic centrosomes.)
R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
R-HSA-380284 (Loss of proteins required for interphase microtubule organization from the centrosome.)
R-HSA-380320 (Recruitment of NuMA to mitotic centrosomes.)
R-HSA-400253 (Circadian Clock.)
R-HSA-5620912 (Anchoring of the basal body to the plasma membrane.)
R-HSA-6791226 (Major pathway of rRNA processing in the nucleolus and cytosol.)
R-HSA-8854518 (AURKA Activation by TPX2.)
UniProt A2I2P2 P48730 Q96KZ6 Q9BTN5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3UYS 3UYT 3UZP 4HGT 4HNF 4KB8 4KBA 4KBC 4KBK 4TN6 4TW9 4TWC 5IH4 5IH5 5IH6 5MQV 5W4W
CREDO 3UYS 3UYT 3UZP 4HGT 4HNF 4KB8 4KBA 4KBC 4KBK 4TN6 4TW9 4TWC 5IH4 5IH5 5IH6 5MQV 5W4W
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