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Target Report Card

Target Name and Classification

Target ID CHEMBL2821
Target Type SINGLE PROTEIN
Preferred Name Coagulation factor XII
Synonyms Beta-factor XIIa part 1 | Beta-factor XIIa part 2 | Coagulation factor XII | Coagulation factor XIIa heavy chain | Coagulation factor XIIa light chain | F12 | HAF | Hageman factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Coagulation factor XII SINGLE PROTEIN P00748

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000131187
Ensembl ENSG00000131187
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0051787 (misfolded protein binding)
GO Biological Process GO:0002353 (plasma kallikrein-kinin cascade)
GO:0002542 (Factor XII activation)
GO:0006508 (proteolysis)
GO:0007596 (blood coagulation)
GO:0007597 (blood coagulation, intrinsic pathway)
GO:0007599 (hemostasis)
GO:0010756 (positive regulation of plasminogen activation)
GO:0016485 (protein processing)
GO:0016540 (protein autoprocessing)
GO:0030193 (regulation of blood coagulation)
GO:0030194 (positive regulation of blood coagulation)
GO:0031638 (zymogen activation)
GO:0042730 (fibrinolysis)
GO:0045087 (innate immune response)
GO:0051788 (response to misfolded protein)
GO:0051919 (positive regulation of fibrinolysis)
Wikipedia Factor_XII

Target Cross References - Protein

CGD Angioedema, hereditary, type III
Human Protein Atlas ENSG00000131187
IntAct P00748
Guide to Pharmacology 2361
Open Targets ENSG00000131187
PharmGKB PA161
Reactome R-HSA-140837 (Intrinsic Pathway of Fibrin Clot Formation.)
UniProt P00748 P78339

Target Cross References - Domain

InterPro IPR000001 (Kringle.)
IPR000083 (Fibronectin_type1.)
IPR000562 (FN_type2_col-bd.)
IPR000742 (EGF-like_dom.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR009003 (Peptidase_S1_PA.)
IPR013032 (EGF-like_CS.)
IPR013806 (Kringle-like.)
IPR014394 (Coagulation_fac_XIIa/HGFA.)
IPR018056 (Kringle_CS.)
IPR018114 (TRYPSIN_HIS.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00008 (EGF)
PF00039 (fn1)
PF00040 (fn2)
PF00051 (Kringle)
PF00089 (Trypsin)

Target Cross References - Structure

PDBe 4BDW 4BDX 4XDE 4XE4
CREDO 4BDW 4BDX 4XDE 4XE4
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