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Target Report Card

Target Name and Classification

Target ID CHEMBL2814
Preferred Name DNA topoisomerase I
Synonyms DNA topoisomerase 1 | DNA topoisomerase I | Top-1 | Top1
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > isomerase

Target Components

Component Description Relationship Accession
DNA topoisomerase 1 SINGLE PROTEIN Q04750

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0000228 (nuclear chromosome)
GO:0000932 (cytoplasmic mRNA processing body)
GO:0001650 (fibrillar center)
GO:0001651 (dense fibrillar component)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0009330 (DNA topoisomerase complex (ATP-hydrolyzing))
GO:0031298 (replication fork protection complex)
GO:0032993 (protein-DNA complex)
GO:0043204 (perikaryon)
GO Molecular Function GO:0001046 (core promoter sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003697 (single-stranded DNA binding)
GO:0003916 (DNA topoisomerase activity)
GO:0003917 (DNA topoisomerase type I activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016853 (isomerase activity)
GO:0019904 (protein domain specific binding)
GO:0031490 (chromatin DNA binding)
GO:0044877 (macromolecular complex binding)
GO:0097100 (supercoiled DNA binding)
GO Biological Process GO:0006260 (DNA replication)
GO:0006265 (DNA topological change)
GO:0006338 (chromatin remodeling)
GO:0007059 (chromosome segregation)
GO:0007623 (circadian rhythm)
GO:0009303 (rRNA transcription)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0032922 (circadian regulation of gene expression)
GO:0040016 (embryonic cleavage)
GO:0042493 (response to drug)
GO:0048511 (rhythmic process)

Target Cross References - Protein

canSAR Q04750
IntAct Q04750
Reactome R-MMU-4615885 (SUMOylation of DNA replication proteins.)
UniProt A2A4B7 Q04750

Target Cross References - Domain

InterPro IPR001631 (TopoI.)
IPR008336 (TopoI_DNA-bd_euk.)
IPR011010 (DNA_brk_join_enz.)
IPR013030 (DNA_topo_DNA_db_N_dom2.)
IPR013034 (DNA_topo_DNA_db_N_dom1.)
IPR013499 (TopoI_euk.)
IPR013500 (TopoI_cat_euk.)
IPR014711 (TopoI_cat_a-hlx-sub_euk.)
IPR014727 (TopoI_cat_a/b-sub_euk.)
IPR018521 (TopoI_AS.)
IPR025834 (TopoI_C_dom.)
IPR036202 (TopoI_DNA-bd_euk_N_sf.)
Pfam PF01028 (Topoisom_I)
PF02919 (Topoisom_I_N)
PF14370 (Topo_C_assoc)