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Target Report Card

Target Name and Classification

Target ID CHEMBL2812
Preferred Name Aldehyde dehydrogenase
Synonyms ALDH class 2 | ALDH-E2 | ALDH1 | Aldehyde dehydrogenase, mitochondrial | Aldh2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldehyde dehydrogenase, mitochondrial SINGLE PROTEIN P11884

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO Molecular Function GO:0004029 (aldehyde dehydrogenase (NAD) activity)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
GO:0042802 (identical protein binding)
GO:0070404 (NADH binding)
GO Biological Process GO:0001889 (liver development)
GO:0006068 (ethanol catabolic process)
GO:0008152 (metabolic process)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0032570 (response to progesterone)
GO:0032870 (cellular response to hormone stimulus)
GO:0033574 (response to testosterone)
GO:0035094 (response to nicotine)
GO:0043066 (negative regulation of apoptotic process)
GO:0055093 (response to hyperoxia)
GO:0055114 (oxidation-reduction process)
GO:0071398 (cellular response to fatty acid)

Target Cross References - Protein

canSAR P11884
IntAct P11884
Guide to Pharmacology 2595
UniProt P11884 Q6Q288 Q6Q289 Q6Q290 Q8K3V8 Q91ZD7

Target Cross References - Domain

InterPro IPR015590 (Aldehyde_DH_dom.)
IPR016160 (Ald_DH_CS_CYS.)
IPR016161 (Ald_DH/histidinol_DH.)
IPR016162 (Ald_DH_N.)
IPR016163 (Ald_DH_C.)
IPR029510 (Ald_DH_CS_GLU.)
Pfam PF00171 (Aldedh)

Target Cross References - Structure

PDBe 2V1S 2V1T 3AWR 3AX2 3AX3 3AX5 5AZ8
CREDO 2V1S 2V1T 3AWR 3AX2 3AX3 3AX5 5AZ8