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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2803
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase ZAP-70
Synonyms 70 kDa zeta-chain associated protein | SRK | Syk-related tyrosine kinase | Tyrosine-protein kinase ZAP-70 | ZAP70
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase syk family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase ZAP-70 SINGLE PROTEIN P43403

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115085
Ensembl ENSG00000115085
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0042101 (T cell receptor complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001784 (phosphotyrosine binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006955 (immune response)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030217 (T cell differentiation)
GO:0035556 (intracellular signal transduction)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0042110 (T cell activation)
GO:0042113 (B cell activation)
GO:0042127 (regulation of cell proliferation)
GO:0043366 (beta selection)
GO:0045059 (positive thymic T cell selection)
GO:0045060 (negative thymic T cell selection)
GO:0045061 (thymic T cell selection)
GO:0045087 (innate immune response)
GO:0045582 (positive regulation of T cell differentiation)
GO:0046638 (positive regulation of alpha-beta T cell differentiation)
GO:0046641 (positive regulation of alpha-beta T cell proliferation)
GO:0046777 (protein autophosphorylation)
GO:0050850 (positive regulation of calcium-mediated signaling)
GO:0050852 (T cell receptor signaling pathway)
GO:0070489 (T cell aggregation)
GO:0072678 (T cell migration)
Wikipedia ZAP70

Target Cross References - Protein

canSAR P43403
CGD Selective T-cell defect
Human Protein Atlas ENSG00000115085
IntAct P43403
Guide to Pharmacology 2285
Open Targets ENSG00000115085
PharmGKB PA37447
Pharos P43403 (Tchem)
Reactome R-HSA-202430 (Translocation of ZAP-70 to Immunological synapse.)
R-HSA-202433 (Generation of second messenger molecules.)
UniProt A6NFP4 P43403 Q6PIA4 Q8IXD6 Q9UBS6

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR012234 (Tyr_kinase_non-rcpt_SYK/ZAP70.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR023420 (Kinase_SYK/ZAP-70_inter-SH2_sf.)
IPR035838 (SYK/ZAP-70_N_SH2.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76
CREDO 1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76
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