ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2801
Target Type SINGLE PROTEIN
Preferred Name CaM kinase II delta
Synonyms CAMK2D | CAMKD | CaM kinase II subunit delta | CaMK-II subunit delta | Calcium/calmodulin-dependent protein kinase type II subunit delta
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk2 family

Target Components

Component Description Relationship Accession
Calcium/calmodulin-dependent protein kinase type II subunit delta SINGLE PROTEIN Q13557

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097164 CaM kinase II PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145349
Ensembl ENSG00000145349
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0030666 (endocytic vesicle membrane)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0034704 (calcium channel complex)
GO:0042383 (sarcolemma)
GO:0043005 (neuron projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004683 (calmodulin-dependent protein kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019871 (sodium channel inhibitor activity)
GO:0031432 (titin binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0044325 (ion channel binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001558 (regulation of cell growth)
GO:0002026 (regulation of the force of heart contraction)
GO:0003254 (regulation of membrane depolarization)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0007399 (nervous system development)
GO:0008016 (regulation of heart contraction)
GO:0010613 (positive regulation of cardiac muscle hypertrophy)
GO:0010649 (regulation of cell communication by electrical coupling)
GO:0010666 (positive regulation of cardiac muscle cell apoptotic process)
GO:0010880 (regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
GO:0010881 (regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)
GO:0016310 (phosphorylation)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018107 (peptidyl-threonine phosphorylation)
GO:0030154 (cell differentiation)
GO:0032469 (endoplasmic reticulum calcium ion homeostasis)
GO:0046777 (protein autophosphorylation)
GO:0051259 (protein oligomerization)
GO:0055119 (relaxation of cardiac muscle)
GO:0060314 (regulation of ryanodine-sensitive calcium-release channel activity)
GO:0060333 (interferon-gamma-mediated signaling pathway)
GO:0060341 (regulation of cellular localization)
GO:0071277 (cellular response to calcium ion)
GO:0086003 (cardiac muscle cell contraction)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:0098901 (regulation of cardiac muscle cell action potential)
GO:0098909 (regulation of cardiac muscle cell action potential involved in regulation of contraction)
GO:1900034 (regulation of cellular response to heat)
GO:1901725 (regulation of histone deacetylase activity)
GO:1901844 (regulation of cell communication by electrical coupling involved in cardiac conduction)
GO:1901897 (regulation of relaxation of cardiac muscle)
GO:1902306 (negative regulation of sodium ion transmembrane transport)
GO:1902514 (regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)
GO:2000650 (negative regulation of sodium ion transmembrane transporter activity)
Wikipedia CAMK2D

Target Cross References - Protein

canSAR Q13557
Human Protein Atlas ENSG00000145349
IntAct Q13557
Guide to Pharmacology 1558
Open Targets ENSG00000145349
PharmGKB PA92
Pharos Q13557 (Tchem)
Reactome R-HSA-3371571 (HSF1-dependent transactivation.)
R-HSA-399719 (Trafficking of AMPA receptors.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442742 (CREB phosphorylation through the activation of Ras.)
R-HSA-442982 (Ras activation upon Ca2+ influx through NMDA receptor.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
R-HSA-5578775 (Ion homeostasis.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-877300 (Interferon gamma signaling.)
R-HSA-936837 (Ion transport by P-type ATPases.)
UniProt A8MVS8 Q13557 Q52PK4 Q59G21 Q8N553 Q9UGH6 Q9UQE9

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR013543 (Ca/CaM-dep_prot_kinase-assoc.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR032710 (NTF2-like_dom_sf.)
Pfam PF00069 (Pkinase)
PF08332 (CaMKII_AD)

Target Cross References - Structure

PDBe 2VN9 2W2C 2WEL 3GP2 5VLO 6AYW
CREDO 2VN9 2W2C 2WEL 3GP2 5VLO 6AYW
spacer
spacer