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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2778
Target Type SINGLE PROTEIN
Preferred Name Ileal bile acid transporter
Synonyms ASBT | ASBT | Apical sodium-dependent bile acid transporter | IBAT | ISBT | ISBT | Ileal Na(+)/bile acid cotransporter | Ileal sodium-dependent bile acid transporter | Ileal sodium/bile acid cotransporter | NTCP2 | Na(+)-dependent ileal bile acid transporter | SLC10A2 | Sodium/taurocholate cotransporting polypeptide, ileal | Solute carrier family 10 member 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc10 family of sodium-bile acid co-transporters

Target Components

Component Description Relationship Accession
Ileal sodium/bile acid cotransporter SINGLE PROTEIN Q12908

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3039515 ELOBIXIBAT Ileal bile acid transporter inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125255
Ensembl ENSG00000125255
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005902 (microvillus)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0008508 (bile acid:sodium symporter activity)
GO:0015293 (symporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0015721 (bile acid and bile salt transport)
GO:0055085 (transmembrane transport)
Wikipedia SLC10A2

Target Cross References - Protein

CGD Bile acid malabsorption, primary
Human Protein Atlas ENSG00000125255
Guide to Pharmacology 960
Open Targets ENSG00000125255
PharmGKB PA318
Reactome R-HSA-159418 (Recycling of bile acids and salts.)
UniProt A1L4F4 Q12908 Q13839

Target Cross References - Domain

InterPro IPR002657 (BilAc:Na_symport/Acr3.)
IPR004710 (Bilac:Na_transpt.)
IPR030207 (SLC10A2.)
Pfam PF01758 (SBF)
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