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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL277
Target Type SINGLE PROTEIN
Preferred Name Muscarinic acetylcholine receptor M5
Synonyms Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor M5
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M5 SINGLE PROTEIN P08911

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907609 Muscarinic acetylcholine receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005575 (cellular_component)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO Biological Process GO:0001696 (gastric acid secretion)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0015872 (dopamine transport)
GO:0019226 (transmission of nerve impulse)
GO:0060304 (regulation of phosphatidylinositol dephosphorylation)

Target Cross References - Protein

canSAR P08911
IntAct P08911
Guide to Pharmacology 17
Reactome R-RNO-390648 (Muscarinic acetylcholine receptors.)
R-RNO-416476 (G alpha (q) signalling events.)
UniProt P08911

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000502 (Musac_Ach_M5_rcpt.)
IPR000995 (Musac_Ach_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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