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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL275
Preferred Name Phosphodiesterase 4B
Synonyms DPDE4 | DPDE4 | PDE32 | PDE4B | cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > phosphodiesterase > phosphodiesterase 4 > phosphodiesterase 4b

Target Components

Component Description Relationship Accession
cAMP-specific 3',5'-cyclic phosphodiesterase 4B SINGLE PROTEIN Q07343

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363066 3',5'-cyclic phosphodiesterase PROTEIN FAMILY
CHEMBL2095153 Phosphodiesterase; PDE3 & PDE4 SELECTIVITY GROUP
CHEMBL2093863 Phosphodiesterase 4 PROTEIN FAMILY
CHEMBL2111340 Phosphodiesterase 4 and 5 (PDE4 and PDE5) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000184588
Ensembl ENSG00000184588
GO Cellular Component GO:0000930 (gamma-tubulin complex)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005891 (voltage-gated calcium channel complex)
GO:0008021 (synaptic vesicle)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0030018 (Z disc)
GO:0043197 (dendritic spine)
GO:0060076 (excitatory synapse)
GO:0071944 (cell periphery)
GO Molecular Function GO:0004114 (3',5'-cyclic-nucleotide phosphodiesterase activity)
GO:0004115 (3',5'-cyclic-AMP phosphodiesterase activity)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0030552 (cAMP binding)
GO:0043015 (gamma-tubulin binding)
GO:0044325 (ion channel binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001780 (neutrophil homeostasis)
GO:0006198 (cAMP catabolic process)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0030593 (neutrophil chemotaxis)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032743 (positive regulation of interleukin-2 production)
GO:0035690 (cellular response to drug)
GO:0050852 (T cell receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071872 (cellular response to epinephrine stimulus)
GO:0086004 (regulation of cardiac muscle cell contraction)
GO:1901841 (regulation of high voltage-gated calcium channel activity)
GO:1901898 (negative regulation of relaxation of cardiac muscle)
Wikipedia PDE4B

Target Cross References - Protein

canSAR Q07343
Human Protein Atlas ENSG00000184588
IntAct Q07343
Guide to Pharmacology 1301
Open Targets ENSG00000184588
PharmGKB PA33129
Reactome R-HSA-180024 (DARPP-32 events.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt A5YW33 O15443 Q07343 Q13945 Q5TEK4 Q5TEK5 Q5TEK6

Target Cross References - Domain

InterPro IPR002073 (PDEase_catalytic_dom.)
IPR003607 (HD/PDEase_dom.)
IPR023088 (PDEase.)
IPR023174 (PDEase_CS.)
IPR036971 (PDEase_catalytic_dom_sf.)
Pfam PF00233 (PDEase_I)

Target Cross References - Structure

PDBe 1F0J 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ More...
CREDO 1F0J 1RO6 1RO9 1ROR 1TB5 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1Y2H 1Y2J 2CHM 2QYL 3D3P 3FRG 3G45 3GWT 3HC8 3HDZ More...