ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL2749
Target Type SINGLE PROTEIN
Preferred Name Platelet-derived growth factor receptor beta
Synonyms Beta platelet-derived growth factor receptor | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD_antigen=CD140b | PDGF-R-beta | PDGFR-1 | PDGFR-beta | Pdgfr | Pdgfr1 | Pdgfrb | Platelet-derived growth factor receptor 1 | Platelet-derived growth factor receptor beta
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase pdgfr family

Target Components

Component Description Relationship Accession
Platelet-derived growth factor receptor beta SINGLE PROTEIN P05622

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096980 Platelet-derived growth factor receptor PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031226 (intrinsic component of plasma membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0043202 (lysosomal lumen)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0004871 (signal transducer activity)
GO:0005017 (platelet-derived growth factor-activated receptor activity)
GO:0005019 (platelet-derived growth factor beta-receptor activity)
GO:0005102 (receptor binding)
GO:0005161 (platelet-derived growth factor receptor binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0038085 (vascular endothelial growth factor binding)
GO:0043548 (phosphatidylinositol 3-kinase binding)
GO:0048407 (platelet-derived growth factor binding)
GO Biological Process GO:0001568 (blood vessel development)
GO:0001701 (in utero embryonic development)
GO:0001822 (kidney development)
GO:0001894 (tissue homeostasis)
GO:0006024 (glycosaminoglycan biosynthetic process)
GO:0006468 (protein phosphorylation)
GO:0006807 (nitrogen compound metabolic process)
GO:0006935 (chemotaxis)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0008284 (positive regulation of cell proliferation)
GO:0010863 (positive regulation of phospholipase C activity)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030097 (hemopoiesis)
GO:0030325 (adrenal gland development)
GO:0030335 (positive regulation of cell migration)
GO:0032516 (positive regulation of phosphoprotein phosphatase activity)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0035441 (cell migration involved in vasculogenesis)
GO:0035556 (intracellular signal transduction)
GO:0035789 (metanephric mesenchymal cell migration)
GO:0035791 (platelet-derived growth factor receptor-beta signaling pathway)
GO:0035793 (positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)
GO:0035909 (aorta morphogenesis)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0038091 (positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0046488 (phosphatidylinositol metabolic process)
GO:0046777 (protein autophosphorylation)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048568 (embryonic organ development)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0048705 (skeletal system morphogenesis)
GO:0048745 (smooth muscle tissue development)
GO:0050730 (regulation of peptidyl-tyrosine phosphorylation)
GO:0050921 (positive regulation of chemotaxis)
GO:0055003 (cardiac myofibril assembly)
GO:0060326 (cell chemotaxis)
GO:0060437 (lung growth)
GO:0060947 (cardiac vascular smooth muscle cell differentiation)
GO:0060981 (cell migration involved in coronary angiogenesis)
GO:0061298 (retina vasculature development in camera-type eye)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071670 (smooth muscle cell chemotaxis)
GO:0072223 (metanephric glomerular mesangium development)
GO:0072262 (metanephric glomerular mesangial cell proliferation involved in metanephros development)
GO:0072277 (metanephric glomerular capillary formation)
GO:0090280 (positive regulation of calcium ion import)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
GO:2000491 (positive regulation of hepatic stellate cell activation)
GO:2000573 (positive regulation of DNA biosynthetic process)

Target Cross References - Protein

canSAR P05622
IntAct P05622
Guide to Pharmacology 1804
UniProt P05622

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001824 (Tyr_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027288 (PGFRB.)
IPR036179 (Ig-like_dom_sf.)
Pfam PF00047 (ig)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1AYA 1AYC
CREDO 1AYA 1AYC
spacer
spacer