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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2745
Target Type SINGLE PROTEIN
Preferred Name ATP-citrate synthase
Synonyms ATP-citrate (pro-S-)-lyase | ATP-citrate synthase | Acly | Citrate cleavage enzyme
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
ATP-citrate synthase SINGLE PROTEIN P16638

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0003878 (ATP citrate synthase activity)
GO:0005524 (ATP binding)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0046912 (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)
GO:0048037 (cofactor binding)
GO Biological Process GO:0006084 (acetyl-CoA metabolic process)
GO:0006085 (acetyl-CoA biosynthetic process)
GO:0006101 (citrate metabolic process)
GO:0006629 (lipid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0008152 (metabolic process)
GO:0008610 (lipid biosynthetic process)

Target Cross References - Protein

canSAR P16638
IntAct P16638
UniProt P16638 Q497C7 Q8VIQ1

Target Cross References - Domain

InterPro IPR002020 (Citrate_synthase.)
IPR003781 (CoA-bd.)
IPR005811 (CoA_ligase.)
IPR013816 (ATP_grasp_subdomain_2.)
IPR014608 (ATP-citrate_synthase.)
IPR016040 (NAD(P)-bd_dom.)
IPR016102 (Succinyl-CoA_synth-like.)
IPR016142 (Citrate_synth-like_lrg_a-sub.)
IPR016143 (Citrate_synth-like_sm_a-sub.)
IPR017440 (Cit_synth/succinyl-CoA_lig_AS.)
IPR017866 (Succ-CoA_synthase_bsu_CS.)
IPR032263 (Citrate-bd.)
IPR033847 (Citrt_syn/SCS-alpha_CS.)
Pfam PF00285 (Citrate_synt)
PF00549 (Ligase_CoA)
PF02629 (CoA_binding)
PF16114 (Citrate_bind)
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