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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL273
Target Type SINGLE PROTEIN
Preferred Name Serotonin 1a (5-HT1a) receptor
Synonyms 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A | 5ht1a | Htr1a | Serotonin receptor 1A
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 1A SINGLE PROTEIN P19327

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094123 Serotonin (5-HT) receptor PROTEIN FAMILY
CHEMBL2097171 Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 SELECTIVITY GROUP
CHEMBL2095159 Serotonin 1 (5-HT1) receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043025 (neuronal cell body)
GO:0043203 (axon hillock)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0051378 (serotonin binding)
GO Biological Process GO:0001662 (behavioral fear response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007198 (adenylate cyclase-inhibiting serotonin receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007610 (behavior)
GO:0008283 (cell proliferation)
GO:0014062 (regulation of serotonin secretion)
GO:0031117 (positive regulation of microtubule depolymerization)
GO:0035640 (exploration behavior)
GO:0042053 (regulation of dopamine metabolic process)
GO:0042310 (vasoconstriction)
GO:0042428 (serotonin metabolic process)
GO:0046883 (regulation of hormone secretion)
GO:0050795 (regulation of behavior)
GO:0060259 (regulation of feeding behavior)
GO:0097114 (NMDA glutamate receptor clustering)

Target Cross References - Protein

canSAR P19327
IntAct P19327
Guide to Pharmacology 1
MICAD NBK23137 (5-HT1A receptors)
NBK23250 (5-HT1A serotonin receptors)
NBK23263 (5-HT1A receptors)
NBK23391 (5-HT1A receptors)
UniProt P19327

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000610 (5HT1A_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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