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Target Report Card

Target Name and Classification

Target ID CHEMBL2708
Preferred Name Mitogen-activated protein kinase kinase kinase 11
Synonyms MAP3K11 | Mitogen-activated protein kinase kinase kinase 11 | Mixed lineage kinase 3 | PTK1 | SPRK | Src-homology 3 domain-containing proline-rich kinase | Synonyms=MLK3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase mlk family > tkl protein kinase mlk subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 11 SINGLE PROTEIN Q16584

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL290352 CEP-1347 Mitogen-activated protein kinase kinase kinase 11 inhibitor 3 PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173327
Ensembl ENSG00000173327
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004706 (JUN kinase kinase kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0031434 (mitogen-activated protein kinase kinase binding)
GO:0031435 (mitogen-activated protein kinase kinase kinase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0048365 (Rac GTPase binding)
GO Biological Process GO:0000187 (activation of MAPK activity)
GO:0006468 (protein phosphorylation)
GO:0007017 (microtubule-based process)
GO:0007254 (JNK cascade)
GO:0007256 (activation of JNKK activity)
GO:0007257 (activation of JUN kinase activity)
GO:0008219 (cell death)
GO:0008283 (cell proliferation)
GO:0016310 (phosphorylation)
GO:0043065 (positive regulation of apoptotic process)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0046330 (positive regulation of JNK cascade)
GO:0046777 (protein autophosphorylation)
Wikipedia MAP3K11

Target Cross References - Protein

canSAR Q16584
Human Protein Atlas ENSG00000173327
IntAct Q16584
Guide to Pharmacology 2071
Open Targets ENSG00000173327
PharmGKB PA30594
Pharos Q16584 (Tchem)
Reactome R-HSA-5673000 (RAF activation.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
UniProt B4DS76 Q16584 Q53H00 Q59F06 Q6P2G4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR016231 (MLK1-4.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR035779 (MLK1-3_SH3.)
IPR036028 (SH3-like_dom_sf.)
Pfam PF07714 (Pkinase_Tyr)
PF14604 (SH3_9)

Target Cross References - Structure

PDBe 5K26 5K28
CREDO 5K26 5K28