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Target Report Card

Target Name and Classification

Target ID CHEMBL267
Preferred Name Tyrosine-protein kinase SRC
Synonyms Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src | SRC | SRC1 | p60-Src | pp60c-src
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Proto-oncogene tyrosine-protein kinase Src SINGLE PROTEIN P12931

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3885535 Calmodulin/Proto-oncogene tyrosine-protein kinase Src PROTEIN-PROTEIN INTERACTION
CHEMBL2111336 VEGF-receptor 2 and tyrosine-protein kinase SRC SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL24828 VANDETANIB Tyrosine-protein kinase SRC inhibitor 4 DailyMed
CHEMBL288441 BOSUTINIB Tyrosine-protein kinase SRC inhibitor 4 Expert
CHEMBL217092 SARACATINIB Tyrosine-protein kinase SRC inhibitor 3 PubMed
CHEMBL571546 KX2-391 Tyrosine-protein kinase SRC inhibitor 3 DOI Other PubMed PubMed
CHEMBL3545150 AZM-475271 Tyrosine-protein kinase SRC inhibitor 2 PubMed PubMed
CHEMBL3545133 JNJ-26483327 Tyrosine-protein kinase SRC inhibitor 1 DOI PubMed
CHEMBL3545177 AZD-0424 Tyrosine-protein kinase SRC inhibitor 1 ClinicalTrials PubMed
CHEMBL3545196 PD-0166285 Tyrosine-protein kinase SRC inhibitor 1 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000197122
Ensembl ENSG00000197122
GO Cellular Component GO:0002102 (podosome)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005764 (lysosome)
GO:0005770 (late endosome)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0005901 (caveola)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0032587 (ruffle membrane)
GO:0043005 (neuron projection)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005070 (SH3/SH2 adaptor activity)
GO:0005080 (protein kinase C binding)
GO:0005102 (receptor binding)
GO:0005158 (insulin receptor binding)
GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019899 (enzyme binding)
GO:0019900 (kinase binding)
GO:0019901 (protein kinase binding)
GO:0019904 (protein domain specific binding)
GO:0020037 (heme binding)
GO:0030331 (estrogen receptor binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042169 (SH2 domain binding)
GO:0044325 (ion channel binding)
GO:0044877 (macromolecular complex binding)
GO:0045296 (cadherin binding)
GO:0046875 (ephrin receptor binding)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO:0050839 (cell adhesion molecule binding)
GO:0051219 (phosphoprotein binding)
GO:0051427 (hormone receptor binding)
GO:0070851 (growth factor receptor binding)
GO:0071253 (connexin binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0001545 (primary ovarian follicle growth)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0007155 (cell adhesion)
GO:0007165 (signal transduction)
GO:0007172 (signal complex assembly)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007411 (axon guidance)
GO:0007417 (central nervous system development)
GO:0008283 (cell proliferation)
GO:0009612 (response to mechanical stimulus)
GO:0009615 (response to virus)
GO:0010447 (response to acidic pH)
GO:0010628 (positive regulation of gene expression)
GO:0010632 (regulation of epithelial cell migration)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010641 (positive regulation of platelet-derived growth factor receptor signaling pathway)
GO:0010907 (positive regulation of glucose metabolic process)
GO:0010954 (positive regulation of protein processing)
GO:0014911 (positive regulation of smooth muscle cell migration)
GO:0016032 (viral process)
GO:0016236 (macroautophagy)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0022407 (regulation of cell-cell adhesion)
GO:0030168 (platelet activation)
GO:0030520 (intracellular estrogen receptor signaling pathway)
GO:0030900 (forebrain development)
GO:0031295 (T cell costimulation)
GO:0031648 (protein destabilization)
GO:0031667 (response to nutrient levels)
GO:0031954 (positive regulation of protein autophosphorylation)
GO:0032148 (activation of protein kinase B activity)
GO:0032211 (negative regulation of telomere maintenance via telomerase)
GO:0032463 (negative regulation of protein homooligomerization)
GO:0032869 (cellular response to insulin stimulus)
GO:0033146 (regulation of intracellular estrogen receptor signaling pathway)
GO:0033625 (positive regulation of integrin activation)
GO:0034332 (adherens junction organization)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0034614 (cellular response to reactive oxygen species)
GO:0035556 (intracellular signal transduction)
GO:0035635 (entry of bacterium into host cell)
GO:0036035 (osteoclast development)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0038128 (ERBB2 signaling pathway)
GO:0042127 (regulation of cell proliferation)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043065 (positive regulation of apoptotic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043114 (regulation of vascular permeability)
GO:0043149 (stress fiber assembly)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043393 (regulation of protein binding)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045056 (transcytosis)
GO:0045087 (innate immune response)
GO:0045124 (regulation of bone resorption)
GO:0045453 (bone resorption)
GO:0045737 (positive regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0045785 (positive regulation of cell adhesion)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046628 (positive regulation of insulin receptor signaling pathway)
GO:0046777 (protein autophosphorylation)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048477 (oogenesis)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050847 (progesterone receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0051057 (positive regulation of small GTPase mediated signal transduction)
GO:0051222 (positive regulation of protein transport)
GO:0051385 (response to mineralocorticoid)
GO:0051602 (response to electrical stimulus)
GO:0051726 (regulation of cell cycle)
GO:0051895 (negative regulation of focal adhesion assembly)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0051902 (negative regulation of mitochondrial depolarization)
GO:0051974 (negative regulation of telomerase activity)
GO:0060065 (uterus development)
GO:0060444 (branching involved in mammary gland duct morphogenesis)
GO:0060491 (regulation of cell projection assembly)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070542 (response to fatty acid)
GO:0070555 (response to interleukin-1)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071375 (cellular response to peptide hormone stimulus)
GO:0071393 (cellular response to progesterone stimulus)
GO:0071398 (cellular response to fatty acid)
GO:0071456 (cellular response to hypoxia)
GO:0071498 (cellular response to fluid shear stress)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0071801 (regulation of podosome assembly)
GO:0071803 (positive regulation of podosome assembly)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:0086098 (angiotensin-activated signaling pathway involved in heart process)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:0098609 (cell-cell adhesion)
GO:1900182 (positive regulation of protein localization to nucleus)
GO:1902533 (positive regulation of intracellular signal transduction)
GO:2000386 (positive regulation of ovarian follicle development)
GO:2000394 (positive regulation of lamellipodium morphogenesis)
GO:2000573 (positive regulation of DNA biosynthetic process)
GO:2000641 (regulation of early endosome to late endosome transport)
GO:2000811 (negative regulation of anoikis)
GO:2001237 (negative regulation of extrinsic apoptotic signaling pathway)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
GO:2001286 (regulation of caveolin-mediated endocytosis)
Wikipedia Src_(gene)

Target Cross References - Protein

canSAR P12931
Human Protein Atlas ENSG00000197122
IntAct P12931
Guide to Pharmacology 2206
Open Targets ENSG00000197122
PharmGKB PA36111
Pharos P12931 (Tclin)
Reactome R-HSA-1227986 (Signaling by ERBB2.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1295596 (Spry regulation of FGF signaling.)
R-HSA-1433557 (Signaling by SCF-KIT.)
R-HSA-1433559 (Regulation of KIT signaling.)
R-HSA-171007 (p38MAPK events.)
R-HSA-177929 (Signaling by EGFR.)
R-HSA-180292 (GAB1 signalosome.)
R-HSA-186763 (Downstream signal transduction.)
R-HSA-191647 (c-src mediated regulation of Cx43 function and closure of gap junctions.)
R-HSA-2029481 (FCGR activation.)
R-HSA-210990 (PECAM1 interactions.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-354192 (Integrin alphaIIb beta3 signaling.)
R-HSA-354194 (GRB2:SOS provides linkage to MAPK signaling for Integrins.)
R-HSA-372708 (p130Cas linkage to MAPK signaling for integrins.)
R-HSA-375165 (NCAM signaling for neurite out-growth.)
R-HSA-389356 (CD28 co-stimulation.)
R-HSA-389513 (CTLA4 inhibitory signaling.)
R-HSA-391160 (Signal regulatory protein family interactions.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
R-HSA-418592 (ADP signalling through P2Y purinoceptor 1.)
R-HSA-418885 (DCC mediated attractive signaling.)
R-HSA-418886 (Netrin mediated repulsion signals.)
R-HSA-428542 (Regulation of commissural axon pathfinding by SLIT and ROBO.)
R-HSA-430116 (GP1b-IX-V activation signalling.)
R-HSA-437239 (Recycling pathway of L1.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-456926 (Thrombin signalling through proteinase activated receptors (PARs).)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-5673000 (RAF activation.)
R-HSA-5674135 (MAP2K and MAPK activation.)
R-HSA-6802946 (Signaling by moderate kinase activity BRAF mutants.)
R-HSA-6802948 (Signaling by high-kinase activity BRAF mutants.)
R-HSA-6802949 (Signaling by RAS mutants.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-6802955 (Paradoxical activation of RAF signaling by kinase inactive BRAF.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-69231 (Cyclin D associated events in G1.)
R-HSA-8853659 (RET signaling.)
R-HSA-8874081 (MET activates PTK2 signaling.)
R-HSA-8876493 (InlA-mediated entry of Listeria monocytogenes into host cells.)
R-HSA-8934593 (Regulation of RUNX1 Expression and Activity.)
R-HSA-8934903 (Receptor Mediated Mitophagy.)
R-HSA-8940973 (RUNX2 regulates osteoblast differentiation.)
R-HSA-8941858 (Regulation of RUNX3 expression and activity.)
UniProt E1P5V4 P12931 Q76P87 Q86VB9 Q9H5A8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR036028 (SH3-like_dom_sf.)
IPR036860 (SH2_dom_sf.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F More...
CREDO 1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F More...