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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2662
Target Type SINGLE PROTEIN
Preferred Name Kynurenine/alpha-aminoadipate aminotransferase
Synonyms 2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AadAT | Aadat | Alpha-aminoadipate aminotransferase | KAT/AadAT | Kat2 | Kynurenine aminotransferase II | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial SINGLE PROTEIN Q64602

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005739 (mitochondrion)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0008483 (transaminase activity)
GO:0016212 (kynurenine-oxoglutarate transaminase activity)
GO:0016740 (transferase activity)
GO:0030170 (pyridoxal phosphate binding)
GO:0042803 (protein homodimerization activity)
GO:0047536 (2-aminoadipate transaminase activity)
GO Biological Process GO:0006103 (2-oxoglutarate metabolic process)
GO:0006536 (glutamate metabolic process)
GO:0009058 (biosynthetic process)
GO:0019441 (tryptophan catabolic process to kynurenine)
GO:0033512 (L-lysine catabolic process to acetyl-CoA via saccharopine)
GO:0070189 (kynurenine metabolic process)
GO:0097052 (L-kynurenine metabolic process)

Target Cross References - Protein

canSAR Q64602
Reactome R-RNO-71064 (Lysine catabolism.)
R-RNO-71240 (Tryptophan catabolism.)
UniProt Q64602

Target Cross References - Domain

InterPro IPR004839 (Aminotransferase_I/II.)
IPR015421 (PyrdxlP-dep_Trfase_major_sub1.)
IPR015422 (PyrdxlP-dep_Trfase_major_sub2.)
IPR015424 (PyrdxlP-dep_Trfase.)
Pfam PF00155 (Aminotran_1_2)
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