ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL2658
Preferred Name Neuronal acetylcholine receptor subunit beta-4
Synonyms Acrb4 | Chrnb4 | N-alpha 2 | Neuronal acetylcholine receptor non-alpha-2 chain | Neuronal acetylcholine receptor subunit beta-4
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > nicotinic acetylcholine receptor > nicotinic acetylcholine receptor beta subunit

Target Components

Component Description Relationship Accession
Neuronal acetylcholine receptor subunit beta-4 SINGLE PROTEIN P12392

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL1907595 Neuronal acetylcholine receptor; alpha4/beta4 PROTEIN COMPLEX
CHEMBL3137276 Nicotinic acetylcholine receptor alpha6/alpha3/beta4 PROTEIN COMPLEX
CHEMBL2094110 Neuronal acetylcholine receptor PROTEIN COMPLEX GROUP
CHEMBL1907590 Neuronal acetylcholine receptor; alpha2/beta4 PROTEIN COMPLEX
CHEMBL1907593 Neuronal acetylcholine receptor; alpha3/beta4 PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005892 (acetylcholine-gated channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0043005 (neuron projection)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0005216 (ion channel activity)
GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0015464 (acetylcholine receptor activity)
GO:0022848 (acetylcholine-gated cation channel activity)
GO:0042166 (acetylcholine binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0001508 (action potential)
GO:0006811 (ion transport)
GO:0006939 (smooth muscle contraction)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007271 (synaptic transmission, cholinergic)
GO:0007274 (neuromuscular synaptic transmission)
GO:0007626 (locomotory behavior)
GO:0034220 (ion transmembrane transport)
GO:0035094 (response to nicotine)
GO:0035095 (behavioral response to nicotine)
GO:0042391 (regulation of membrane potential)
GO:0051291 (protein heterooligomerization)
GO:0051971 (positive regulation of transmission of nerve impulse)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060079 (excitatory postsynaptic potential)
GO:0060084 (synaptic transmission involved in micturition)
GO:0098655 (cation transmembrane transport)

Target Cross References - Protein

canSAR P12392
IntAct P12392
Reactome R-RNO-629587 (Highly sodium permeable acetylcholine nicotinic receptors.)
R-RNO-629594 (Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.)
R-RNO-629597 (Highly calcium permeable nicotinic acetylcholine receptors.)
R-RNO-6798695 (Neutrophil degranulation.)
UniProt P12392 Q63361

Target Cross References - Domain

InterPro IPR002394 (Nicotinic_acetylcholine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
IPR036719 (Neuro-gated_channel_TM_sf.)
IPR036734 (Neur_chan_lig-bd_sf.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)