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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2655
Preferred Name Adenylate cyclase type IX
Synonyms AC9 | ACIX | ADCY9 | ATP pyrophosphate-lyase 9 | Adenylate cyclase type 9 | Adenylate cyclase type IX | Adenylyl cyclase 9 | KIAA0520
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Adenylate cyclase type 9 SINGLE PROTEIN O60503

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2097167 Adenylate cyclase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162104
Ensembl ENSG00000162104
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004016 (adenylate cyclase activity)
GO:0005524 (ATP binding)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0003091 (renal water homeostasis)
GO:0006171 (cAMP biosynthetic process)
GO:0007165 (signal transduction)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0019933 (cAMP-mediated signaling)
GO:0034199 (activation of protein kinase A activity)
GO:0035556 (intracellular signal transduction)
GO:0071377 (cellular response to glucagon stimulus)
GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
Wikipedia ADCY9

Target Cross References - Protein

canSAR O60503
Human Protein Atlas ENSG00000162104
IntAct O60503
Open Targets ENSG00000162104
PharmGKB PA30
Reactome R-HSA-163359 (Glucagon signaling in metabolic regulation.)
R-HSA-163615 (PKA activation.)
R-HSA-164378 (PKA activation in glucagon signalling.)
R-HSA-170660 (Adenylate cyclase activating pathway.)
R-HSA-170670 (Adenylate cyclase inhibitory pathway.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-418594 (G alpha (i) signalling events.)
R-HSA-418597 (G alpha (z) signalling events.)
R-HSA-432040 (Vasopressin regulates renal water homeostasis via Aquaporins.)
R-HSA-5610787 (Hedgehog 'off' state.)
UniProt A7E2V5 A7E2X2 D3DUD1 O60273 O60503 Q4ZHT9 Q4ZIR5 Q9BWT4 Q9UGP2

Target Cross References - Domain

InterPro IPR001054 (A/G_cyclase.)
IPR018297 (A/G_cyclase_CS.)
IPR029787 (Nucleotide_cyclase.)
Pfam PF00211 (Guanylate_cyc)