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Target Report Card

Target Name and Classification

Target ID CHEMBL265
Preferred Name Dopamine D1 receptor
Synonyms D(1A) dopamine receptor | Dopamine D1 receptor | Drd1 | Drd1a
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > dopamine receptor

Target Components

Component Description Relationship Accession
D(1A) dopamine receptor SINGLE PROTEIN P18901

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093868 Dopamine receptor PROTEIN FAMILY
CHEMBL2096910 Dopamine receptors; D1 & D2 SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0043198 (dendritic shaft)
GO:0043679 (axon terminus)
GO:0044326 (dendritic spine neck)
GO:0044327 (dendritic spine head)
GO Molecular Function GO:0001588 (dopamine neurotransmitter receptor activity, coupled via Gs)
GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004952 (dopamine neurotransmitter receptor activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008144 (drug binding)
GO:0019903 (protein phosphatase binding)
GO:0031701 (angiotensin receptor binding)
GO:0031750 (D3 dopamine receptor binding)
GO:0044877 (macromolecular complex binding)
GO:0046982 (protein heterodimerization activity)
GO:0051117 (ATPase binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0001963 (synaptic transmission, dopaminergic)
GO:0001975 (response to amphetamine)
GO:0006469 (negative regulation of protein kinase activity)
GO:0006886 (intracellular protein transport)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007191 (adenylate cyclase-activating dopamine receptor signaling pathway)
GO:0007212 (dopamine receptor signaling pathway)
GO:0007416 (synapse assembly)
GO:0007626 (locomotory behavior)
GO:0008306 (associative learning)
GO:0008542 (visual learning)
GO:0010243 (response to organonitrogen compound)
GO:0014070 (response to organic cyclic compound)
GO:0014823 (response to activity)
GO:0019229 (regulation of vasoconstriction)
GO:0019722 (calcium-mediated signaling)
GO:0021756 (striatum development)
GO:0021769 (orbitofrontal cortex development)
GO:0030336 (negative regulation of cell migration)
GO:0032094 (response to food)
GO:0032355 (response to estradiol)
GO:0032526 (response to retinoic acid)
GO:0032869 (cellular response to insulin stimulus)
GO:0035094 (response to nicotine)
GO:0035106 (operant conditioning)
GO:0035176 (social behavior)
GO:0042311 (vasodilation)
GO:0042321 (negative regulation of circadian sleep/wake cycle, sleep)
GO:0042493 (response to drug)
GO:0043200 (response to amino acid)
GO:0043269 (regulation of ion transport)
GO:0043278 (response to morphine)
GO:0045471 (response to ethanol)
GO:0045762 (positive regulation of adenylate cyclase activity)
GO:0045838 (positive regulation of membrane potential)
GO:0048148 (behavioral response to cocaine)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0048545 (response to steroid hormone)
GO:0060158 (phospholipase C-activating dopamine receptor signaling pathway)
GO:0060548 (negative regulation of cell death)
GO:0071456 (cellular response to hypoxia)
GO:1900273 (positive regulation of long-term synaptic potentiation)
GO:2000253 (positive regulation of feeding behavior)

Target Cross References - Protein

canSAR P18901
IntAct P18901
Guide to Pharmacology 214
MICAD NBK23009 (D1 dopamine receptors)
NBK23252 (Dopamine D1 receptor)
UniProt P18901 P21669

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000929 (Dopamine_rcpt.)
IPR001413 (Dopamine_D1_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)