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Target Report Card

Target Name and Classification

Target ID CHEMBL2649
Preferred Name Cyclooxygenase-1
Synonyms COX-1 | Cox-1 | Cox1 | Cyclooxygenase-1 | PGH synthase 1 | PGHS-1 | PHS 1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 | Ptgs1
Organism Mus musculus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Prostaglandin G/H synthase 1 SINGLE PROTEIN P22437

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111349 Prostaglandin G/H synthase (cyclooxygenase) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0001750 (photoreceptor outer segment)
GO:0005635 (nuclear envelope)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0016020 (membrane)
GO:0031090 (organelle membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0004601 (peroxidase activity)
GO:0004666 (prostaglandin-endoperoxide synthase activity)
GO:0016491 (oxidoreductase activity)
GO:0020037 (heme binding)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006693 (prostaglandin metabolic process)
GO:0006954 (inflammatory response)
GO:0006979 (response to oxidative stress)
GO:0007612 (learning)
GO:0007613 (memory)
GO:0008217 (regulation of blood pressure)
GO:0010700 (negative regulation of norepinephrine secretion)
GO:0019233 (sensory perception of pain)
GO:0019371 (cyclooxygenase pathway)
GO:0030216 (keratinocyte differentiation)
GO:0032811 (negative regulation of epinephrine secretion)
GO:0035633 (maintenance of blood-brain barrier)
GO:0042127 (regulation of cell proliferation)
GO:0045907 (positive regulation of vasoconstriction)
GO:0045987 (positive regulation of smooth muscle contraction)
GO:0055114 (oxidation-reduction process)
GO:0097756 (negative regulation of blood vessel diameter)
GO:0098869 (cellular oxidant detoxification)

Target Cross References - Protein

canSAR P22437
IntAct P22437
Reactome R-MMU-140180 (COX reactions.)
R-MMU-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
UniProt P22437

Target Cross References - Domain

InterPro IPR000742 (EGF-like_dom.)
IPR010255 (Haem_peroxidase.)
IPR019791 (Haem_peroxidase_animal.)
IPR029580 (COX-1.)
IPR037120 (Haem_peroxidase_sf.)
Pfam PF03098 (An_peroxidase)