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Target Report Card

Target Name and Classification

Target ID CHEMBL263
Target Type SINGLE PROTEIN
Preferred Name Type-1B angiotensin II receptor
Synonyms AT1B | AT3 | Agtr1 | Agtr1b | Angiotensin II type-1B receptor | At1b | Type-1B angiotensin II receptor
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > angiotensin receptor

Target Components

Component Description Relationship Accession
Type-1B angiotensin II receptor SINGLE PROTEIN P29089

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094250 Angiotensin II receptor (AT-1) type-1 PROTEIN FAMILY
CHEMBL2094112 Angiotensin II receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0012506 (vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0031983 (vesicle lumen)
GO Molecular Function GO:0001596 (angiotensin type I receptor activity)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004945 (angiotensin type II receptor activity)
GO:0017046 (peptide hormone binding)
GO:0043621 (protein self-association)
GO Biological Process GO:0001568 (blood vessel development)
GO:0001666 (response to hypoxia)
GO:0001822 (kidney development)
GO:0001991 (regulation of systemic arterial blood pressure by circulatory renin-angiotensin)
GO:0001999 (renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure)
GO:0002019 (regulation of renal output by angiotensin)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007584 (response to nutrient)
GO:0009651 (response to salt stress)
GO:0019229 (regulation of vasoconstriction)
GO:0035094 (response to nicotine)
GO:0035902 (response to immobilization stress)
GO:0038166 (angiotensin-activated signaling pathway)
GO:0042493 (response to drug)
GO:0042756 (drinking behavior)
GO:0043627 (response to estrogen)
GO:0045777 (positive regulation of blood pressure)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0086097 (phospholipase C-activating angiotensin-activated signaling pathway)
GO:0090190 (positive regulation of branching involved in ureteric bud morphogenesis)
GO:1990776 (response to angiotensin)

Target Cross References - Protein

canSAR P29089
Guide to Pharmacology 34
Reactome R-RNO-375276 (Peptide ligand-binding receptors.)
R-RNO-416476 (G alpha (q) signalling events.)
UniProt P29089

Target Cross References - Domain

InterPro IPR000190 (ATII_AT1_rcpt.)
IPR000248 (ATII_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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