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Target Report Card

Target Name and Classification

Target ID CHEMBL2622
Preferred Name Aldose reductase
Synonyms Akr1b1 | Akr1b4 | Aldehyde reductase | Aldose reductase | Aldr1
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Aldose reductase SINGLE PROTEIN P07943

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005615 (extracellular space)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0032838 (cell projection cytoplasm)
GO:0033010 (paranodal junction)
GO:0042629 (mast cell granule)
GO:0043220 (Schmidt-Lanterman incisure)
GO:0048471 (perinuclear region of cytoplasm)
GO:0097454 (Schwann cell microvillus)
GO Molecular Function GO:0004032 (alditol:NADP+ 1-oxidoreductase activity)
GO:0016491 (oxidoreductase activity)
GO:0043795 (glyceraldehyde oxidoreductase activity)
GO Biological Process GO:0001894 (tissue homeostasis)
GO:0003091 (renal water homeostasis)
GO:0005996 (monosaccharide metabolic process)
GO:0006061 (sorbitol biosynthetic process)
GO:0009414 (response to water deprivation)
GO:0010033 (response to organic substance)
GO:0018931 (naphthalene metabolic process)
GO:0031098 (stress-activated protein kinase signaling cascade)
GO:0035809 (regulation of urine volume)
GO:0042415 (norepinephrine metabolic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0044597 (daunorubicin metabolic process)
GO:0044598 (doxorubicin metabolic process)
GO:0046427 (positive regulation of JAK-STAT cascade)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0055114 (oxidation-reduction process)
GO:0060135 (maternal process involved in female pregnancy)
GO:0071475 (cellular hyperosmotic salinity response)
GO:0072001 (renal system development)
GO:0072061 (inner medullary collecting duct development)
GO:0097066 (response to thyroid hormone)
GO:0097238 (cellular response to methylglyoxal)
GO:1901653 (cellular response to peptide)

Target Cross References - Protein

canSAR P07943
Reactome R-RNO-196108 (Pregnenolone biosynthesis.)
R-RNO-5652227 (Fructose biosynthesis.)
UniProt P07943

Target Cross References - Domain

InterPro IPR018170 (Aldo/ket_reductase_CS.)
IPR020471 (Aldo/keto_reductase.)
IPR023210 (NADP_OxRdtase_dom.)
IPR036812 (NADP_OxRdtase_dom_sf.)
Pfam PF00248 (Aldo_ket_red)