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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2608
Target Type SINGLE PROTEIN
Preferred Name Lysosomal alpha-glucosidase
Synonyms 70 kDa lysosomal alpha-glucosidase | 76 kDa lysosomal alpha-glucosidase | Acid maltase | Aglucosidase alfa | GAA | Lysosomal alpha-glucosidase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Lysosomal alpha-glucosidase SINGLE PROTEIN P10253

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3833502 Alpha glucosidase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1561 MIGLITOL Lysosomal alpha-glucosidase inhibitor 4 DailyMed PubMed
CHEMBL460785 DUVOGLUSTAT HYDROCHLORIDE Lysosomal alpha-glucosidase stabiliser 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171298
Ensembl ENSG00000171298
GO Cellular Component GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0035577 (azurophil granule membrane)
GO:0043202 (lysosomal lumen)
GO:0070062 (extracellular exosome)
GO:0070821 (tertiary granule membrane)
GO:0101003 (ficolin-1-rich granule membrane)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004553 (hydrolase activity, hydrolyzing O-glycosyl compounds)
GO:0004558 (alpha-1,4-glucosidase activity)
GO:0004574 (oligo-1,6-glucosidase activity)
GO:0016787 (hydrolase activity)
GO:0016798 (hydrolase activity, acting on glycosyl bonds)
GO:0030246 (carbohydrate binding)
GO:0032450 (maltose alpha-glucosidase activity)
GO:0090599 (alpha-glucosidase activity)
GO Biological Process GO:0000023 (maltose metabolic process)
GO:0002026 (regulation of the force of heart contraction)
GO:0002086 (diaphragm contraction)
GO:0003007 (heart morphogenesis)
GO:0005975 (carbohydrate metabolic process)
GO:0005977 (glycogen metabolic process)
GO:0005980 (glycogen catabolic process)
GO:0005985 (sucrose metabolic process)
GO:0006006 (glucose metabolic process)
GO:0006941 (striated muscle contraction)
GO:0007040 (lysosome organization)
GO:0007626 (locomotory behavior)
GO:0008152 (metabolic process)
GO:0009888 (tissue development)
GO:0043181 (vacuolar sequestering)
GO:0043312 (neutrophil degranulation)
GO:0046716 (muscle cell cellular homeostasis)
GO:0050884 (neuromuscular process controlling posture)
GO:0050885 (neuromuscular process controlling balance)
GO:0060048 (cardiac muscle contraction)
Wikipedia Acid_alpha-glucosidase

Target Cross References - Protein

CGD Glycogen storage disease II
Human Protein Atlas ENSG00000171298
IntAct P10253
Guide to Pharmacology 2611
Open Targets ENSG00000171298
PharmGKB PA28476
Reactome R-HSA-5357572 (Lysosomal glycogen catabolism.)
R-HSA-5357609 (Glycogen storage disease type II (GAA).)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt P10253 Q09GN4 Q14351 Q16302 Q8IWE7

Target Cross References - Domain

InterPro IPR000322 (Glyco_hydro_31.)
IPR000519 (P_trefoil_dom.)
IPR011013 (Gal_mutarotase_sf_dom.)
IPR013780 (Glyco_hydro_b.)
IPR017853 (Glycoside_hydrolase_SF.)
IPR017957 (P_trefoil_CS.)
IPR025887 (Glyco_hydro_31_N_dom.)
IPR030458 (Glyco_hydro_31_AS.)
IPR030459 (Glyco_hydro_31_CS.)
IPR031727 (Gal_mutarotase_N.)
Pfam PF00088 (Trefoil)
PF01055 (Glyco_hydro_31)
PF13802 (Gal_mutarotas_2)
PF16863 (NtCtMGAM_N)

Target Cross References - Structure

PDBe 5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8
CREDO 5KZW 5KZX 5NN3 5NN4 5NN5 5NN6 5NN8
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