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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2591
Target Type SINGLE PROTEIN
Preferred Name Glutamate [NMDA] receptor subunit epsilon 4
Synonyms EB11 | GRIN2D | GluN2D | GluN2D | Glutamate [NMDA] receptor subunit epsilon-4 | Glutamate receptor ionotropic, NMDA 2D | N-methyl D-aspartate receptor subtype 2D | NMDAR2D | NMDAR2D | NR2D
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ionotropic glutamate receptor > nmda receptor

Target Components

Component Description Relationship Accession
Glutamate receptor ionotropic, NMDA 2D SINGLE PROTEIN O15399

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094124 Glutamate [NMDA] receptor PROTEIN COMPLEX GROUP
CHEMBL3038505 Ionotropic glutamate receptor NMDA 1/2D PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105464
Ensembl ENSG00000105464
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0017146 (NMDA selective glutamate receptor complex)
GO:0030054 (cell junction)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004970 (ionotropic glutamate receptor activity)
GO:0004972 (NMDA glutamate receptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005216 (ion channel activity)
GO:0005234 (extracellular-glutamate-gated ion channel activity)
GO:0005515 (protein binding)
GO:0022849 (glutamate-gated calcium ion channel activity)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0001964 (startle response)
GO:0006811 (ion transport)
GO:0007420 (brain development)
GO:0008344 (adult locomotory behavior)
GO:0019722 (calcium-mediated signaling)
GO:0035235 (ionotropic glutamate receptor signaling pathway)
GO:0048167 (regulation of synaptic plasticity)
GO:0051930 (regulation of sensory perception of pain)
GO:0060079 (excitatory postsynaptic potential)
GO:0097553 (calcium ion transmembrane import into cytosol)
GO:0098976 (excitatory chemical synaptic transmission)
Wikipedia GRIN2D

Target Cross References - Protein

canSAR O15399
Human Protein Atlas ENSG00000105464
IntAct O15399
Open Targets ENSG00000105464
PharmGKB PA28982
Pharos O15399 (Tclin)
Reactome R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442982 (Ras activation upon Ca2+ influx through NMDA receptor.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6794361 (Neurexins and neuroligins.)
R-HSA-8849932 (Synaptic adhesion-like molecules.)
UniProt O15399

Target Cross References - Domain

InterPro IPR001320 (Iontro_rcpt.)
IPR001508 (Iono_rcpt_met.)
IPR001828 (ANF_lig-bd_rcpt.)
IPR019594 (Glu/Gly-bd.)
IPR028082 (Peripla_BP_I.)
Pfam PF00060 (Lig_chan)
PF01094 (ANF_receptor)
PF10613 (Lig_chan-Glu_bd)
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