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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL2590
Target Type SINGLE PROTEIN
Preferred Name Aminopeptidase N
Synonyms ANPEP | AP-M | AP-N | Alanyl aminopeptidase | Aminopeptidase M | Aminopeptidase N | CD_antigen=CD13 | Microsomal aminopeptidase | gp130 | pAPN
Organism Sus scrofa
Species Group No
Protein Target Classification
  • enzyme > protease > metallo protease > metallo protease mae clan > metallo protease m1 family

Target Components

Component Description Relationship Accession
Aminopeptidase N SINGLE PROTEIN P15145

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0004177 (aminopeptidase activity)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0042277 (peptide binding)
GO:0046872 (metal ion binding)
GO:0070006 (metalloaminopeptidase activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0006508 (proteolysis)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0007275 (multicellular organism development)
GO:0008217 (regulation of blood pressure)
GO:0016032 (viral process)
GO:0030154 (cell differentiation)
GO:0043171 (peptide catabolic process)
GO:0046718 (viral entry into host cell)

Target Cross References - Protein

canSAR P15145
UniProt P15145 Q29242

Target Cross References - Domain

InterPro IPR001930 (Peptidase_M1.)
IPR014782 (Peptidase_M1_N.)
IPR024571 (ERAP1-like_C_dom.)
IPR034016 (M1_APN-typ.)
Pfam PF01433 (Peptidase_M1)
PF11838 (ERAP1_C)

Target Cross References - Structure

PDBe 4F5C 4FKE 4FKH 4FKK 4HOM 4NAQ 4NZ8 4OU3 5LDS 5LG6 6BUY 6BV0 6BV1 6BV2 6BV3 6BV4
CREDO 4F5C 4FKE 4FKH 4FKK 4HOM 4NAQ 4NZ8 4OU3 5LDS 5LG6 6BUY 6BV0 6BV1 6BV2 6BV3 6BV4
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